For those with limited morphology experience – how would you describe the findings on the bone marrow?
Further testing on bone marrow samples awaited
- – cytogenetics – which translocation may you find?
- – cell markers? what would you expect?
Urology have reviewed the patient and planning a stent insertion. He remains on HDU, receiving rasburicase daily.
good points regarding chemo for this patient! Any further opinions on potential treatment? CNS prophylaxis?
What regimes are generally used in burkitts lymphoma?
How would management change if this patient was HIV positive??
TeamHaem 
chromosome 8 is involved Burkitt’s lymphoma (c-myc gene). t(8;14)
CD10, CD19, CD20, BCL 6 positive, negative for BCL2 and TdT
Treatment option include R- CODOX-M/ IVAC (includes CNS prophylaxis)
HIV postive: same treatment alongwith HAART
Thanks!
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