Case 18 – update 6

For those with limited morphology experience – how would you describe the findings on the bone marrow?

Further testing on bone marrow samples awaited

  • – cytogenetics – which translocation may you find?
  • – cell markers?  what would you expect?

Urology have reviewed the patient and planning a stent insertion.  He remains on HDU, receiving rasburicase daily.

good points regarding chemo for this patient! Any further opinions on potential treatment? CNS prophylaxis?

What regimes are generally used in burkitts lymphoma?

How would management change if this patient was HIV positive??

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2 Responses to Case 18 – update 6

  1. Muhammad Mohsin says:

    chromosome 8 is involved Burkitt’s lymphoma (c-myc gene). t(8;14)
    CD10, CD19, CD20, BCL 6 positive, negative for BCL2 and TdT

    Treatment option include R- CODOX-M/ IVAC (includes CNS prophylaxis)

    HIV postive: same treatment alongwith HAART

    • teamhaem says:

      Thanks!

      Please reply on Twitter and always include #teamhaem to allow others to follow your comments. Please join in the debate and learn about haematological problems along the way. The case will continue to evolve over the coming week so keep checking #teamhaem for more information.

      Please note – all cases on TeamHaem are entirely fictional to protect patient confidentiality.

      TeamHaem are not a position of authority. It is an educational platform to allow discussion

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