Thanks for all the tweets regarding further investigations!

In the “real world” I guess we have to prioritise the investigations required – think of our budget and workload!

A few have suggested von willebrand screen, which seems the most obvious next step in a patient who is stabilised.  This screen can be requested by the current team and does not need specialist input.

VWF:Ag   65 (50-150 IU/dl)

VWF:Rico 25 (50-150 IU/dl)

FVIII binding assay  85% (70-200%)

Based on these investigations what would your differential be?

What could effect von willebrand screening results?

What are the criteria for making a diagnosis of von willebrand?

any further investigations now?