Our patient has >2×10⁹ plasma cells in peripheral blood without a history of myeloma consistent with a diagnosis of primary plasma cell leukaemia (pPCL). Flow is typical of  pPCL – myeloma markers with CD56- and CD20+. Our patient had a normal karyotype, which is slightly unusual for pPCL.

What cytogenetic abnormalities would you typically expect for pPCL in comparison to newly diagnosed multiple myeloma?

How would you treat this patient?

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