Case 75 – update 1

Thanks for everyones contributions. The following results are now back:


SFLC kappa: lambda ratio: 6543.

Igs and serum electrophoresis: Immuneparesis and IgA kappa paraprotein 18

B2 microglobulin 8.7. Albumin 28.

Bone marrow biopsy: 66% plasma cells morphologically.

Flow cytometry (blood and BM): CD 20+, CD38+, CD138+, CD56-

MRI in progress



What is the diagnosis?

What’s the criteria for plasma cell leukaemia?

How do we differentiate between myeloma and primary plasma cell leukaemia?

What are the cytogenetics results likely to be?


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