You are in a joint obstetric haematology clinic and have been referred a 24 year old lady who is 13 weeks pregnant P0 G1
You take a family history and find her father and paternal uncle have severe Haemophillia A. See pedigree below:
1) How likely is she to be a carrier of Haemophillia A?
2) What options are there for pre delivery diagnosis of Haemophillia A ?