Case 108 – Update 2!

Thank you for everyone’s contributions in obtaining the diagnosis of Nodular Lymphocyte-Predominant Hodgkin Lymphoma (NLPHL)!

The lymph node morphology demonstrates large atypical cells with multiple nucleoli (lymphocyte-predominant cells) embedded within follicles.

The IHC is as follows:

  • Lymphocyte-predominant cells:CD20+, CD45+, CD75+, PAX5+, CD5-, CD15-, CD30-, EBV-
  • Follicles (T cell rosettes around the LP cells): CD4+, CD57+, PD1+

This histopathological form is consistent with the typical pattern of NLPHL (pattern A or B).

A PETCT has revealed stage 1A disease with several non-bulky unilateral cervical lymph nodes.


  1. How would you treat our patient?
  2. Any additional information you’d like to help aid your decision?


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