Thank you for everyone’s contributions in obtaining the diagnosis of Nodular Lymphocyte-Predominant Hodgkin Lymphoma (NLPHL)!
The lymph node morphology demonstrates large atypical cells with multiple nucleoli (lymphocyte-predominant cells) embedded within follicles.
The IHC is as follows:
- Lymphocyte-predominant cells:CD20+, CD45+, CD75+, PAX5+, CD5-, CD15-, CD30-, EBV-
- Follicles (T cell rosettes around the LP cells): CD4+, CD57+, PD1+
This histopathological form is consistent with the typical pattern of NLPHL (pattern A or B).
A PETCT has revealed stage 1A disease with several non-bulky unilateral cervical lymph nodes.
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