Case 121 – Update 1!

Our 48 year old patient with relapsed/refractory DLBCL is referred for consideration of CAR T-cell therapy. She is managed with IVE chemotherapy as a ‘bridging treatment’ and is subsequently admitted for CAR T-cell infusion.

You are the on-call haematology SpR. You are called at 2am regarding our patient. She is 5 days post CAR T-cell infusion, and the SHO on-call is concerned she is ‘septic.’ Current observations are:

Temp 39.2

BP 84/60

HR 78

SpO2 92% O/A

What would be your next steps in the acute investigation and management of this patient?


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