Case 126 – Update 3!

Thank you for everyone’s contributions so far!

As advised by yourselves we have commenced our 57 year old gentleman who has newly diagnosed T-PLL on Alemtuzumab with the aim of consolidating with an allogenic stem cell transplant. He had been tolerating it well having only  experienced mild infusion reactions with cycle 1 and 2. However he has now presented with marked diarrhoea post his 4th cycle of treatment.

Questions:

  1. What is the differential diagnosis for this?
  2. What investigations would you perform?

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