Case 127 – Update 2

Our 31 year old female patient with newly diagnosed CML in chronic phase is commenced on dasatinib 100 mg OD with the aim of gaining a faster deep molecular response (DMR).

3 years later (patient is now 34)…..

  • She has tolerated the drug well – no evidence of pleural effusions
  • She has had a complete haematological response (CHR)
  • Her BCR-ABL1 to ABL1 ratio has been hovering around 0.05% for the last 2 years. She is now asking to stop the drug to start trying for a family

What is the evidence around stopping TKI therapy? How would you counsel the patient in the best way forward?


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