Thank you for your ongoing input.

Unfortunately the investigations performed to assess our patients new onset B symptoms and mild lymphocytosis whilst on acalabrutinib have revealed that he has diffuse large B cell lymphoma:

1. LDH: 1200
2. CT: widespread mild lymphadenopathy (predmoninantly <3cm) and a large 8cm mass in retroperitoneum
3. PETCT: Retroperitoneal mass and intrabdominal nodes significantly more FDG avid than other other low volume lymphadenopathy (SUV max 15).
4. Retroperitoneal mass histology: DLBCL

Questions:

1. What further investigations/additional information would you want to acertain?
2. How would you manage this patient?

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