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Author Archives: TeamHaem
Case 100 (part C) – the beginning
You are in a GP surgery and are asked to perform a full blood count on a 60 year old male who is awaiting a knee replacement for osteoarthritis. He has a past history of glaucoma, hypertension and a myocardial … Continue reading
Posted in Chronic leukaemia, Lymphoma
Tagged Lymphocytosis
Case 99 – Summary
Thank you for your contribution in our #TeamHaem case this week. This week we have been looking at Diamond Blackfan anaemia (DBA). This is a rare, genetically and clinically heterogeneous, inherited red cell aplasia. It is one of the Inherited … Continue reading
Case 99 – update 5
Genetic testing on both parents and her brother are carried out and are all negative. Hence this is a de novo mutation of RPL5 in our little girl. You also carry out HLA typing on her and her brother, who … Continue reading
Case 99 – update 4
Based on a diagnosis of Diamond Blackfan anaemia, a decision is made to start a regular transfusion programme until she is over 1 year of age to minimise the impact of steroids on her growth. It will also allow her … Continue reading
Posted in Anaemia, Paediatric haematology
Tagged anaemia, Diamond Blackfan anaemia, family screening, genetics, paediatrics, Pure red cell aplasia
Case 99 – update 3
A bone marrow biopsy has been carried out: (see below) Aspirate shows erythroid hypoplasia but no dysplastic features. Cellularity is normal and megakaryocyte & granulocyte lineages are normal. For interest, also see Trephine IHC with Glycophorin-C staining – demonstrating reduced … Continue reading
Posted in Anaemia, Laboratory morphology, Paediatric haematology
Tagged anaemia, blood transfusion, Bone marrow, morphology, paediatrics
Case 99 – update 2
A blood film has been looked at, no specific findings are noted except for anaemia and occasional spherocytes. There are no red cell fragments, no dysplastic features and no primitive cells. EMA & G6PD are in progress. Parvovirus B19 serology … Continue reading
Posted in Anaemia, Paediatric haematology
Tagged anaemia, blood transfusion, paediatrics
Case 99 – update 1
You call Mum and repeat the baby’s blood count urgently. Her repeat bloods show: Hb 63g/L Platelet 506 x 10^9 MCV 99.9fL, WBC 9.36x 10^9 Neutrophil 3.46 x 10^9 You explain to Mum that her baby is anaemic and you … Continue reading
Posted in Anaemia, Paediatric haematology
Tagged anaemia, paediatrics
Case 99 – the beginning
Welcome to our new #TeamHaem case. You are working in General practice. You see a 9 month old baby girl in the morning. Her mother tells you that in recent weeks she has needed more naps and has not been … Continue reading
Posted in Anaemia, Paediatric haematology
Tagged anaemia, paediatrics
Case 98 – summary
Following several obinutuzumab reactions, which resulted in overnight hospital admissions, our patient decided he did not wish to continue with obinutuzumab. He continues on chlorambucil monotherapy and has tolerated it reasonably well and his disease appears to be responding. Thankyou … Continue reading
Posted in Chronic leukaemia
Tagged Bone marrow transplant, chemotherapy, Chronic lymphocytic leukaemia, Cytogenetics, elderly, Lymphocytosis
Case 98 – part 2 – update 1
We have confirmed progression in our patient’s CLL. There is no evidence of haemolysis. He has a pmh of HTN, diabetes, mild copd and osteoarthritis which limits his mobility. He has an ecog of 2 (was 1 prior to the … Continue reading
Posted in Chronic leukaemia
Tagged chemotherapy, Chronic lymphocytic leukaemia, Cytogenetics, elderly, Lymphocytosis
Case 98 – part 2 – the beginning
Thankyou for your help with part 1. Here is the second part of this weeks case. You are in the haematology clinic and are seeing an 82 year old gentleman who was diagnosed with CLL 10 years ago. He has … Continue reading
Posted in Chronic leukaemia
Tagged chemotherapy, Chronic lymphocytic leukaemia, Cytogenetics, elderly, Lymphocytosis
Case 98 – part 1 – update 3
Our patient has been started on venetoclax and has had an excellent response. Following discussions with our patient and referral to the transplant team he has decided to go ahead with a sibling allo SCT. What considerations are there for … Continue reading
Case 98 – part 1 – update 2
Our patient has been diagnosed with CLL and has been found to have deletion 17p on cytogenetics. He has now been on ibrutinib for 15 months. He has tolerated it very well and did get an improvement in his Hb … Continue reading
Posted in Chronic leukaemia
Tagged Chronic lymphocytic leukaemia, Cytogenetics, Lymphocytosis
Case 98 – part 1 – update 1
We have found our patient has a lymphocytosis with mild anaemia and mild thrombocytopenia. Blood film show lymphocytosis with mature lymphocytes and smear cells. We have some flow results. What do these show? What is our diagnosis? Would you like … Continue reading
Posted in Chronic leukaemia, Laboratory morphology
Tagged Chronic lymphocytic leukaemia, Flow cytometry, Lymphocytosis
Case 98 – part 1 – the beginning
Welcome to our new case! We will do 2 short cases this week. In our first case we start in general practice. A 42 year old patient has come to see you as he has been training for a marathon … Continue reading
Posted in Chronic leukaemia
