Category Archives: Acute leukaemia

Case 77 – summary

Case 77 Summary   Thanks to everyone who contributed to the case this week.   Our case started with a blood film to test our morphology skills.  We picked up that the blood film showed: Dysplastic neutrophils Blasts NRBCs Tear … Continue reading

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Case 77 – update 2

Bone marrow results: 13% blasts evidence of dysplasia in the erythroid and myeloid cell lines Cytogenetics:trisomy 8   How would you classify this patient? What would be your approach to management?

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Case 77 – update 1

So far, we have a 54 year old male who is pancytopenic.  He demonstrates features of myelodysplasia on blood film. we have not had any clinical details, but most have suggested admission which does not seem unreasonable given the patients … Continue reading

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Case 77 – the beginning

  Let’s start this case with a blood film. Can you describe the findings on the film? What information would you like as the registrar reviewing the film?   Please reply to us (@TeamHaem) on Twitter and always include #TeamHaem … Continue reading

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Case 69 – part 2 – summary

This patient has a medical emergency. She has pancytopenia with evidence of bleeding. There are abnormal promyelocytes and faggot cells (below) which are indicative of acute promyelocytic leukaemia. Acute promyelocytic leukaemia is a subtype of acute myeloid leukaemia characterised by … Continue reading

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Case 69 – part 2 – the beginning

A 21 year old female presents with epistaxis and bleeding gums and the following blood count: Hb 69g/L Platelets 27×10*9/L WCC 12×10*9/L     Questions What is your immediate management? What tests would you like to perform?   Please reply … Continue reading

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Case 51 – summary

Thank you for all of your input this week. This week we looked at a patient who was diagnosed with AML in the 3rd trimester of pregnancy. She initially presented with a rash which, following a biopsy, was diagnosed as … Continue reading

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Case 51 – update 2

Our patient has been diagnosed with AML. FISH for t(15;17) is negative. The full cytogenetic report is awaited.  She is currently an inpatient and following discussion with the haematology, obstetric, neonatology and anaesthetic team she and the teams caring for … Continue reading

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Case 51 – update 1

So we have our first update. Our 20 year old lady who is now 32 weeks pregnant attended with a rash. This is her first pregnancy. She has been increasingly tired over the last 6 weeks, but has put this … Continue reading

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Case 51 – the beginning

After a short break welcome to our new case! This week we start in general practice.  A 20 year old lady attends who found out she was pregnant 4 weeks ago. Her dating scan at the time showed that she … Continue reading

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Case 46 – #UnofficialCSIM2 summary

Thank you to those of you who joined in with this case; we hope it was a useful and enjoyable way to learn. We covered a few important topics during the case: the differential for a macrocytic anaemia Investigating macrocytosis … Continue reading

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Case 46 – #UnofficialCSIM2: Update 2

Mr Ordie was referred to Haematology clinic after his initial investigations were unremarkable. Bhy this point his Hb was 85g/l with an MCV of 114fl, platelets of 107. A bone marrow biopsy was performed, which showed: . IMAGE: dysplastic red … Continue reading

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Case 46 – #UnofficialCSIM2 Update 1

Thanks for all your hard work so far. We’ve established that Mr Ordie has a macrocytic anaemia with normal thyroid function tests, normal B12 and folate and no significant alcohol history. He takes methotrexate and folic acid for rheumatoid arthritis. Methotrexate … Continue reading

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Case 46 – #UnofficialCSIM2 Haematology Week

NB To our lonstanding teamhaemers: this week’s case is for medical students. Whilst we may call on some of the usual team to help us out, for now please observe without speaking! Thanks in anticipation.

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Our Second Christmas Cracker: Summary

The first clinical information we gave you is this blood film: You all felt that this film was very worrying and pointed out the numerous blasts, megakarytocyte fragments and abnormal nucleated erythrocytes. When we revealed that this was a newborn … Continue reading

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Our second Christmas Cracker!

So here is our last mini-Christmas case. Have a look at this film: What is going on? Answers on a hashtag (#teamhaem) – all ideas welcome! Please reply on Twitter and always include #teamhaem to allow others to follow your … Continue reading

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Morphology – case 5 (summary)

Thanks for all of your responses. The full blood count of our patient showed Hb 82g/L, PLT 34×10*9/L, WCC 6.2×10*9/L, neuts 0.34×10*9/L. The film showed abnormal leukaemic blast cells which are occasionally bilobed and heavily granulated with stacks of Auer … Continue reading

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Morphology – case 5

You look at the blood film for a 57 year old patient with the clinical details of ‘confusion ?UTI’. Questions What do you see? What’s your next move? Please reply on Twitter and always include #teamhaem to allow others to … Continue reading

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Morphology week – summary

Slide 1 Answer:  Bernard Soulier syndrome, bleeding disorder characterized by thrombocytopenia and large platelets.  Autosomal recessive inheritance.  Presentation consistent with low or dysfunctional platelets and include easy bruising, nosebleeds, mucosal bleeding, menorrhagia, and, occasionally, GI bleeding. Slide 2 Answer:  Hairy cell leukaemia. … Continue reading

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Morphology week – case 3

What are you findings on this film? What would be your plan for this patient? any further investigation?

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