Category Archives: Bone marrow failure

Case 96 – summary

Posted on 19/07/2018 by TeamHaem

Thank you for participating in our case this week. This week we have been looking at a case of JMML (Juvenile myelomonocytic leukaemia), which is a rare clonal haematopoietic disorder of childhood, characterised by the proliferation of granulocytic and monocytic … Continue reading →

Posted in Bone marrow failure, Myeloproliferative neoplasm, Paediatric haematology | Tagged anaemia, Bone marrow, Bone marrow transplant, Cytogenetics, dysplasia, Flow cytometry, genetics, hepatosplenomegaly, JMML, monocytosis, neutrophilia, paediatrics, thrombocytopenia, weight loss | Leave a comment

Case 96 – update 4

Posted on 18/07/2018 by TeamHaem

The haematology team has now taken over his care. Bone marrow aspirate has demonstrated a hypercellular marrow with left shift, and there are increased myeloid and monocyte lineages. Blast count is about 4%. There is occasional evidence of haemophagocytosis and … Continue reading →

Posted in Bone marrow failure, Myeloproliferative neoplasm, Paediatric haematology | Tagged anaemia, Cytogenetics, dysplasia, genetics, hepatosplenomegaly, JMML, monocytosis, neutrophilia, paediatrics, thrombocytopenia, weight loss | Leave a comment

Case 96 – update 3

Posted on 17/07/2018 by TeamHaem

The blood film has been reported: – leukocytosis with neutrophilia and monocytosis, there is left shift and toxic granulation and vacuolation. Occasional primitive cells ~ 2%. No nucleated RBCs. The appearances might be reactive/infection related, and infection as well as … Continue reading →

Posted in Bone marrow failure, Laboratory morphology, Myeloproliferative neoplasm, Paediatric haematology | Tagged anaemia, Bone marrow, Cytogenetics, dysplasia, Flow cytometry, genetics, hepatosplenomegaly, JMML, monocytosis, neutrophilia, paediatrics, thrombocytopenia, weight loss | Leave a comment

Case 96 – update 2

Posted on 16/07/2018 by TeamHaem

An USS abdomen has been performed which confirms mild hepato-splenomegaly. CXR was reported as normal. Faecal elastase, TTG, TFTs, ILGF1 all normal. You phone the haematology registrar to look at the blood film in view of the abnormal FBC. Questions: … Continue reading →

Posted in Bone marrow failure, Laboratory morphology, Myeloproliferative neoplasm, Paediatric haematology | Tagged anaemia, Blood film, dysplasia, hepatosplenomegaly, JMML, monocytosis, neutrophilia, paediatrics, thrombocytopenia, weight loss | Leave a comment

Case 84 – summary

Posted on 19/10/2017 by TeamHaem

Thank you for all your help with this weeks case! This week we looked at a case of a patient with type 1 Gaucher’s disease . She was found to be mildly anaemia with a mild thrombocytopenia. A CT scan … Continue reading →

Posted in Acquired bleeding, Bone marrow failure, Laboratory morphology, Related to other specialities | Tagged Bone marrow, bruising, Gaucher's disease, morphology, splenomegaly, thrombocytopenia | Leave a comment

Case 84 – update 2

Posted on 18/10/2017 by TeamHaem

So we have the results of our patient’s bone marrow and it looks to be consistent with Gaucher’s disease! Our patient has a raised serum ACE and ferritin which is typical of Gaucher’s disease. Our bone marrow shows the typical … Continue reading →

Case 77 – summary

Posted on 14/05/2017 by TeamHaem

Case 77 Summary Thanks to everyone who contributed to the case this week. Our case started with a blood film to test our morphology skills. We picked up that the blood film showed: Dysplastic neutrophils Blasts NRBCs Tear … Continue reading →

Posted in Acute leukaemia, Bone marrow failure | Tagged Blood film, Cytogenetics, dysplasia, leukaemia, morphology, myelodysplasia | Leave a comment

Case 77 – update 2

Posted on 09/05/2017 by TeamHaem

Bone marrow results: 13% blasts evidence of dysplasia in the erythroid and myeloid cell lines Cytogenetics:trisomy 8 How would you classify this patient? What would be your approach to management?

Posted in Acute leukaemia, Bone marrow failure | Tagged Blood film, Cytogenetics, dysplasia, leukaemia, morphology, myelodysplasia | Leave a comment

Case 77 – update 1

Posted on 08/05/2017 by TeamHaem

So far, we have a 54 year old male who is pancytopenic. He demonstrates features of myelodysplasia on blood film. we have not had any clinical details, but most have suggested admission which does not seem unreasonable given the patients … Continue reading →

Posted in Acute leukaemia, Bone marrow failure | Tagged Blood film, dysplasia, leukaemia, morphology, myelodysplasia | Leave a comment

Case 77 – the beginning

Posted on 07/05/2017 by TeamHaem

Let’s start this case with a blood film. Can you describe the findings on the film? What information would you like as the registrar reviewing the film? Please reply to us (@TeamHaem) on Twitter and always include #TeamHaem … Continue reading →

Posted in Acute leukaemia, Bone marrow failure, Laboratory morphology | Tagged Blood film, morphology | Leave a comment

Case 62 – summary

Posted on 07/08/2016 by TeamHaem

Haematological emergencies Patient A presented with an episode of neutropenic sepsis. As a junior you should be suspicious of someone being neutropenic if they have had recent chemotherapy (usually within the past 1-2 weeks). Reviewing patients previous blood results … Continue reading →

Posted in Bone marrow failure, Myeloma/paraproteins | Tagged Back pain, chemotherapy, neutropenia, neutropenic sepsis, Paraprotein, spinal cord compression, transfusion reaction | Leave a comment

Case 62 – part A – update

Posted on 04/08/2016 by TeamHaem

Patient A has been with us for 48hrs. He stabilised with the prompt treatment delivered on admission, but has spiked a temp in the last 12 hours. His hickman line is still in situ. He was anaemic on admission … Continue reading →

Posted in Bone marrow failure, Transfusion | Tagged blood transfusion, chemotherapy, neutropenia, neutropenic sepsis, transfusion reaction | Leave a comment

Case 62 – part A

Posted on 31/07/2016 by TeamHaem

This week our aim is to develop a few short cases based on emergencies in haematology. The case will be mostly aimed at junior doctors and medical students, timing with the transition of juniors in UK to new rotations this … Continue reading →

Posted in Bone marrow failure | Tagged chemotherapy, neutropenia, neutropenic sepsis | Leave a comment

Case 46 – #UnofficialCSIM2 summary

Posted on 20/10/2015 by TeamHaem

Thank you to those of you who joined in with this case; we hope it was a useful and enjoyable way to learn. We covered a few important topics during the case: the differential for a macrocytic anaemia Investigating macrocytosis … Continue reading →

Posted in Acute leukaemia, Anaemia, Bone marrow failure | Tagged AML, anaemia, Macrocytosis, MDS | Leave a comment

Case 46 – #UnofficialCSIM2: Update 2

Posted on 15/10/2015 by TeamHaem

Mr Ordie was referred to Haematology clinic after his initial investigations were unremarkable. Bhy this point his Hb was 85g/l with an MCV of 114fl, platelets of 107. A bone marrow biopsy was performed, which showed: . IMAGE: dysplastic red … Continue reading →

Posted in Acute leukaemia, Anaemia, Bone marrow failure | Tagged anaemia, Macrocytosis, neutropenia, sepsis | 1 Comment

Case 46 – #UnofficialCSIM2 Update 1

Posted on 13/10/2015 by TeamHaem

Thanks for all your hard work so far. We’ve established that Mr Ordie has a macrocytic anaemia with normal thyroid function tests, normal B12 and folate and no significant alcohol history. He takes methotrexate and folic acid for rheumatoid arthritis. Methotrexate … Continue reading →

Posted in Acute leukaemia, Anaemia, Bone marrow failure | Tagged anaemia, Blood film, Macrocytosis | 3 Comments