Category Archives: Haemoglobinopathy

Case 34 – the beginning

Welcome back to #teamhaem. Great you have you on board with this new case. We start in the emergency department. A 16 year old female with known homozygous sickle cell anaemia presents to your hospital with abdominal pain and feeling lightheaded. … Continue reading

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Case 31 part 5 – summary

The patient’s blood film shows target cells, sickle cell, Howell Jolly bodies. It is difficult to say what the underlying condition is other than a sickling syndrome with hyposplenism. Target cells are often found in all of these disorders, but … Continue reading

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Case 31 part 5 – the beginning

This is the last installment of our morphology week. Name three things important in the management in this patient: Please reply on Twitter and always include #teamhaem to allow others to follow your comments. Please join in the debate and … Continue reading

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Case 31 part 2 – summary

So… we have a leucoerythroblastic film (left shifted granulopoiesis and nucleated red cells) along with tear drop cells. The main differentials the team came up with were: Myelofibrosis (primary or secondary – he did have a haematology past) Metastatic carcinoma … Continue reading

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Case 31 part 2 – update 1

Thanks for all of the suggestions! Here’s a slightly bigger picture of the nucleated red cell and tear drop poikilocytes: The GP tells you the patient used to be under haematology review elsewhere but since moving locally has not been … Continue reading

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Case 31 part 2 – the beginning

This blood film was taken by a local GP as the patient was feeling run down and tired. Hb 95g/L MCV 69fL WCC 14.5×10*9/L PLT 432×10*9/L Questions: Describe the film What is going on? What will you advise the GP? … Continue reading

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Morphology – case 2 (summary)

Thanks for all of the responses to our blood film. We agree with the comments via #teamhaem Sickle cells (more on other parts of the film!) Howell Jolly bodies Target cells Spherocytes Portuguese Man O’ War (!) (not sure Prof … Continue reading

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Morphology – case 2

A blood film has been made from the following patient with the clinical details ‘SOB’. This is the first time you have seen the patient in your hospital. Questions How do you report the film? Who else should you inform of … Continue reading

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Morphology week – summary

Slide 1 Answer:  Bernard Soulier syndrome, bleeding disorder characterized by thrombocytopenia and large platelets.  Autosomal recessive inheritance.  Presentation consistent with low or dysfunctional platelets and include easy bruising, nosebleeds, mucosal bleeding, menorrhagia, and, occasionally, GI bleeding. Slide 2 Answer:  Hairy cell leukaemia. … Continue reading

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Morphology week – case 4

Findings on slide? Potential diagnosis?

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Case 10 – summary

Sickle cell disease Obviously, in most circumstances the patient would be able to inform the medical team that they have a history of sickle cell disease – but to make this case interesting – the diagnosis was not revealed immediately!!! … Continue reading

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Case 10 – update 3

HPLC is performed for this patient. Can anyone described the results? What is HPLC? What does it detect? What are the other forms of sickle cell?

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Case 10 – update 2

So you have established that this patient has sickle cell disease.  She is currently visiting a friend in the area so she had never attended this hospital before. Her pain has been controlled temporpraily with IV morphine, however you are … Continue reading

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Case 10 – update 1

The haemtology registrar is contacted and asked to review the patients blood film. There are at least five features on this film to identify the underlying diagnosis!

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Case 10 – the beginning

An 18 yr old girl presents to A&E complaining of SOB and severe chest pain. Obs show sats of 87% on room air.  BP 135/80, HR 120bpm, RR 28 and apyrexial. Routine bloods have been sent which show that she … Continue reading

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