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Category Archives: Laboratory morphology
Case 88 – parts C and D
You are reviewing the blood film tray and a further two patients are noted to have lymphocytosis Case C Hb 96 g/L WCC 34 (10^9/L) Case D Hb 100 g/L WBC 23 (10^9/L) Can you describe the findings? Do they … Continue reading
Case 88 – part B: update
As requested by some followers Flow cytometry : CD5 + CD23 – SmIg strong FMC7 ++ CD20 ++ CD22 ++ CD19+ CD79b ++ CD200 ++ CD10- Cyclin D1 expression (11:14)(q13:32)negative Splenomegaly noted on examination, with no evidence of lymphadenopathy. … Continue reading
Case 88 – part B
84 year old man Hb 111 WBC 24 Describe the findings on the blood film What further clinical information would you wish to know? further investigations?
Posted in Chronic leukaemia, Laboratory morphology, Lymphoma
Tagged Lymphocytosis, morphology, splenic marginal zone lymphoma
Case 88 – part A
This week we are going to do some quick fire morphology cases. Cases will be centered around a blood film, then added questions based on the diagnosis our followers come up with. Please feel free to add interesting pictures of … Continue reading
Posted in Laboratory morphology, Myeloma/paraproteins
Tagged morphology, myeloma, Plasma cell leukaemia
Case 86 – part C2
Thanks for your help with this short case. We examined this blood film of an unwell female: The most striking abnormality is red cell fragmentation. This can be seen in: AIHA/Evans’ syndrome DIC Pregnancy-associated (HELLP, pre-eclampsia, malignant hypertension, fatty liver of … Continue reading
Posted in Laboratory morphology, Platelet disorders, Thrombosis, Transfusion
Tagged FFP, haemolysis, plasma exchange, red cell fragmentation, thrombosis, TTP
Case 86 – part 3A
A 32 year old female presents with headaches, visual disturbance and fever. Hb 92g/L MCV 99fl Platelets 38×109/l WCC and differential – mild neutrophilia Questions Name some features of the blood film? What are the differential diagnosis? What further investigations … Continue reading
Posted in Laboratory morphology, Thrombosis, Transfusion
Tagged FFP, haemolysis, plasma exchange, red cell fragmentation, thrombosis, TTP
Case 86 – part B2
Thanks for joining in with this short case. We reviewed the blood film of an 82 year old. The FBC was done for diabetes monitoring. There was no recent transfusion and no new medications. The film showed red cell agglutination(3) … Continue reading
Posted in Anaemia, Laboratory morphology, Lymphoma
Tagged Autoimmune haemolytic anaemia, Blood film, cold haemagglutinin disease, DAT, IgM paraprotein
Case 86 – part B1
An 82 year old gentleman has a routine blood count for diabetes monitoring. This is the blood film. Questions: What do you see on the blood film? What questions do you want to ask the patient? Any further investigations? … Continue reading
Posted in Anaemia, Laboratory morphology, Lymphoma
Tagged Autoimmune haemolytic anaemia, Blood film, cold haemagglutinin disease, DAT, IgM paraprotein
Case 86 – part A2
This short case focused on the diagnosis of thalassaemia over iron deficiency. The below factors can help, but there are many overlapping factors and this is more of a guide rather than absolute. Factors that may make this unreliable include … Continue reading
Posted in Anaemia, Haemoglobinopathy, Laboratory morphology
Tagged anaemia, Blood film, haemoglobinopathy, HbEE, HPLC, microcytosis, morphology, thalassaemia
Case 86 – part A1
Welcome to #TeamHaem. This week we are going to look at some blood film morphology. A 21 year old female student has a full blood count done due to fatigue. Hb 100g/L MCV 74fl MCH 21.7pg Platelets 250×109/l WCC and … Continue reading
Posted in Anaemia, Haemoglobinopathy, Laboratory morphology
Tagged anaemia, Blood film, haemoglobinopathy, HbEE, HPLC, microcytosis, morphology, thalassaemia
Case 80 – summary
This week we discussed a 65 year old gentleman who was about to undergo curative surgery for gastric carcinoma. His admission blood tests showed pancytopenia and monocytopenia. The differential diagnosis of pancytopenia includes: Haematological malignancy e.g. myelodysplasia or infiltration … Continue reading
Case 80 – update 3
The immunophenotype was: CD20+, CD79b+, CD22+, CD5 negative, FMC7+, CD103+, CD11c+, CD25+, CD10 negative, CD38 negative, lambda sIg+ This is consistent with hairy cell leukaemia. If further immunophenotypic evidence is required additional stains on the trephine can be undertaken (e.g. … Continue reading
Case 80 – update 2
The blood film showed a population of lymphoid cells with ‘hairy projections’. There was absolute monocytopenia. Both of these are consistent with a diagnosis of hairy cell leukaemia. However, hairy cell leukaemia variant and other low grade lymphoma may have … Continue reading
Case 80 – update 1
Our patient has pancytopenia. On examination there is no specific findings. There is no palpable lymphadenopathy or hepatosplenomegly. There is no rash or gum infiltration. There are no features of chronic liver disease. However review of recent imaging has noted … Continue reading
Case 77 – the beginning
Let’s start this case with a blood film. Can you describe the findings on the film? What information would you like as the registrar reviewing the film? Please reply to us (@TeamHaem) on Twitter and always include #TeamHaem … Continue reading
Posted in Acute leukaemia, Bone marrow failure, Laboratory morphology
Tagged Blood film, morphology
