Category Archives: Lymphoma

Case 56 – update 1

So far we have found out James has not been abroad, he is a lifelong non-smoker and has had no previous procedures. He has no past medical history and has no regular medications. Tests: Wcc 13, Hb 130, plt 260, … Continue reading

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Case 56 – the beginning

James a 48 year old painter presents to his GP with facial pain over his right cheek and a blocked nose with rhinorrhoea. James is given antibiotics for probable sinusitis. Three weeks later his symptoms are worse; he has constant … Continue reading

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Case 55 – Summary

This week we met Mr Jones, a 77 year old man who had an abnormal result when he attended his GP for annual well man bloods. His FBC revealed a moderate thrombocytopenia, a slight lymphocytosis and a normochromic anaemia. When … Continue reading

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Case 55 – Update

The film for this patient showed moderate sized lymphocytes with frequently clefted nuclei and nucleoli. There were no smear cells. The laboratory staff decided to send the specimen for flow cytometry and obtained the following results: CD5+ CD10- CD19+ CD20+ … Continue reading

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Case 55 – the beginning

Good evening. This week we’re going to work together to manage an elderly  patient with a leukocytosis.  Mr Jones is 77 and attends his GP practice for his annual ‘birthday bloods.’ The following results were obtained:  Hb 110 g/dl WCC … Continue reading

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Case 54 – summary

Case A Our first case looked at a blood film of a 48 year old gentleman who had presented with neutropenia and monocytopenia.  This is a common presentation for patients with hairy cell leukaemia and this leaves them susceptible to … Continue reading

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Case 54 – case B

Case B   35 year old female presented with cervical lymphadenopathy and no B symptoms. Histology confirmed hodgkins disease.  PET showed cervical and axillary lymphadenopathy, but no further areas of disease identified.  Bloods showed FBC -normal, LDH 340, ESR 43. … Continue reading

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Case 54 – case A

This week we are going to look at a range of short cases, some of which are morphology based, and most will include MCQ questions.  The discussion does not have to be limited to the basic answer – please feel … Continue reading

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Case 44 – the beginning

Welcome to case 44! Share your thoughts on the following blood film. What other information would you wish to know following review of the film? What advice would you give to the referring clinical? Would you request any further investigations … Continue reading

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Case 42 – summary

Thank you for all of your input! This time we looked at primary CNS lymphoma in an immunocompetent patient. Following 4 cycles of treatment with high dose methotrexate and cytarabine our patient had an excellent response on MRI. He went … Continue reading

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Case 42 – update 2

Our patient was admitted under the medical team following development of left arm weakness, in addition to his left leg weakness. A ct head with contrast has shown an enhancing frontal lesion, with perilesional oedema. An urgent neurosurgical opinion is … Continue reading

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case 42 – update 1

So we have a 47 year old gentleman. No past medical history. Works in telesales. He drinks 70 units of alcohol a week, for the last year. Doesn’t have a great diet, only occasionally eats vegetables. Lives alone, sees his … Continue reading

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Case 42 – the beginning

Welcome to our new case! This week we start in a gp surgery. A 47 year old gentleman attends because he has been having some problems with his memory, he has also noticed that he has been slightly unsteady on … Continue reading

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Case 38 – summary

Thank you for all your input this week!This case looked at a 32 year old gentleman who was diagnosed with burkitt lymphoma (BL) following a 3 week history of sweats, weight loss and an increasing abdominal mass and splenomegally. He … Continue reading

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Case 38 – update 2 

We have some more results. Ct scan shows 19cm splenomegally. There is a large lymph node mass in the left iliac fossa measuring 11×12 cm, there is also other widespread large volume abdominal lymphadenopathy. There are a few 1cm groin … Continue reading

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Case 38 – update 1

So what have we found out? We have a 32 year old male patient who has come back from a 2 year ’round the world’ trip 4/52 ago. He has travelled to Russia, China, India, Argentina, Kenya, Tanzania, Australia, Thailand … Continue reading

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Case 38 – the beginning

Welcome to our new case! Get involved as we see it evolve over the next week with your help. A 32 year old gentleman presents to a&e with a 3 week history of being generally unwell, fever, sweats and abdominal … Continue reading

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Morphology – case 4

A staging bone marrow aspirate and trephine biopsy is performed for a 15 year old female with Hodgkin Lymphoma. Automated full blood count shows: Hb 135g/L, PLT 467×10*9/L, WCC 15.1×10*9/L, neutrophils 13.2×10*9/L. No evidence of Hodgkin Lymphoma is seen on … Continue reading

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Case 22 – summary

Our patient had undergone emergency liver transplant for a paracetamol overdose 9 months ago. He had been well, but on routine clinic visit was noted to be progressively more pancytopenic with deteriorating LFTs. His EBV PCR had risen rapidly and … Continue reading

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Case 22 – update 3

You correctly identified the fact that the high EBV PCR was very suggestive of solid-organ post-transplant Lymphoproliferative Disorder. This is a rare presentation of PTLD, presenting as it does with pancytopenia as the predominant feature. This is occasionally seen and … Continue reading

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