Category Archives: Lymphoma
Case Summary – Burkitts lymphoma Our patients initially presented with abdominal pain, which may have had many underlying aetiologies. With a fairly acute onset there were many diagnoses that needed to be considered. The key learning points in this case … Continue reading
For those with limited morphology experience – how would you describe the findings on the bone marrow? Further testing on bone marrow samples awaited – cytogenetics – which translocation may you find? – cell markers? what would you expect? Urology … Continue reading
The patient is taken to HDU for supportive management. The patient is commenced on treatment for hyperkaleamia. His fluid balance is carefully monitored. He is catherised, given analgesia for his abdominal pain. He requires inotropic support. An uss abdomen is … Continue reading
Initial blood investigations are back. Hb 84 plt 70 wcc 3.4 Na 136 K 6.5 urea 34.5 creatinine 476 Ca 2.31 albumin 26 ALT 47 ALP 67 Bili 27 Any further blood test needed? immediate treatment/investigations? Pt is catheterised with … Continue reading
Ok, so that was a fairly brief history to work at! but it has produced some interesting differential – not all haematological which is useful! The patient gives you the following history: He has been generally unwell/lethargic for the past … Continue reading
First case for 2014! A 42 year old gentleman present to accident and emergency with abdominal pain present for the past 24 hours. How would you assess this patient??!!!
Slide 1 Answer: Bernard Soulier syndrome, bleeding disorder characterized by thrombocytopenia and large platelets. Autosomal recessive inheritance. Presentation consistent with low or dysfunctional platelets and include easy bruising, nosebleeds, mucosal bleeding, menorrhagia, and, occasionally, GI bleeding. Slide 2 Answer: Hairy cell leukaemia. … Continue reading
Some great comments from #teamhaem, including: Hairy cells Howell Jolly bodies Ansiocytosis Nucleated red cells Ansiopoikilocytosis Rouleaux All of the above sound good to us. Some of our followers rightly pointed out that one should not jump to a diagnosis … Continue reading
Below is the blood film from earlier… just higher power. How would you describe it? We’ll let you know what that patient had in the end! Please reply on Twitter and include #teamhaem Please reply on Twitter and always include … Continue reading
How would you describe this blood film?
Hairy cell leukaemia Hairy cell leukaemia is a chronic lymphoid lymphoma of B-cells The hairy cells infiltrate the reticuloendothelial system and interfere with bone marrow function, resulting in bone marrow failure or pancytopenia. They also infiltrate the spleen and … Continue reading
The trephine shows the typical “fried egg cells” seen in hairy cell leukaemia. The cells appear widely spaced due to abundant cytoplasm, with broad projections. This is typical hairy cell which may be found on the peripheral blood film – although in … Continue reading
Image size increased!!! what would you expect to find on immunohistochemistry? how would you manage this patient? what are the options?
The results you have all been waiting for!!! Can you describe this trephine biopsy? Start with the basics! Can you make a diagnosis? If so how would you manage this patient? any more investigations!