Categories
Search
Follow me on Twitter
My Tweets-
Recent Posts
Category Archives: Myeloproliferative neoplasm
Case 96 – summary
Thank you for participating in our case this week. This week we have been looking at a case of JMML (Juvenile myelomonocytic leukaemia), which is a rare clonal haematopoietic disorder of childhood, characterised by the proliferation of granulocytic and monocytic … Continue reading
Case 96 – update 4
The haematology team has now taken over his care. Bone marrow aspirate has demonstrated a hypercellular marrow with left shift, and there are increased myeloid and monocyte lineages. Blast count is about 4%. There is occasional evidence of haemophagocytosis and … Continue reading
Case 96 – update 3
The blood film has been reported: – leukocytosis with neutrophilia and monocytosis, there is left shift and toxic granulation and vacuolation. Occasional primitive cells ~ 2%. No nucleated RBCs. The appearances might be reactive/infection related, and infection as well as … Continue reading
Case 96 – update 2
An USS abdomen has been performed which confirms mild hepato-splenomegaly. CXR was reported as normal. Faecal elastase, TTG, TFTs, ILGF1 all normal. You phone the haematology registrar to look at the blood film in view of the abnormal FBC. Questions: … Continue reading
Case 89 – summary
Thank you for all of the contributions with Case 89 where we encountered a fit 64 year old who presented with progressive anaemia and leucocytosis over the past 6 months. He also had associated weight loss of 0.5 stones … Continue reading
Posted in Anaemia, Myeloproliferative neoplasm
Tagged anaemia, JAK2, leucocytosis, leucoerythroblastic, Macrocytosis, Myelofibrosis
Leave a comment
Case 89 – update 2
Thank you for everyone’s contributions so far! Update of investigation results as requested: Bone marrow trephine: myelofibrosis. BM cytogenetics: monosomy 7 Peripheral blood: JAK2 positive. No circulating blasts identified on blood film. USS abdo: 16cm spleen (Hb 95, Plts 90, … Continue reading
Posted in Anaemia, Myeloproliferative neoplasm, Uncategorised
Tagged anaemia, JAK2, leucocytosis, leucoerythroblastic, Macrocytosis, Myelofibrosis
Leave a comment
Case 89 – update 1
Thanks for everyones contributions so far. Further information now available as requested by yourselves: Patient decline over past 6 months – 0.5 stone weight loss, no night sweats / fevers. Marked lethargy and generally feeling ‘achey’. Poor appetite but no … Continue reading
Case 89 – the beginning
A 64 year old man is referred to haematology outpatients with progressive chronic anaemia and leucocytosis. He has previously been very fit but has become very lethargic over the past few months. Hb 95, MCV 103, Plts 90, WCC 17, … Continue reading
Posted in Anaemia, Myeloproliferative neoplasm
Tagged anaemia, leucocytosis, leucoerythroblastic, Macrocytosis
Leave a comment
Case 52 – summary
Our case was based on a 34 year old lady with a new diagnosis of CML. Diagnosis CML in a proportion of patients is diagnosed on routine blood tests prior to onset of symptoms. However, symptoms can include: lethargy shortness … Continue reading
Posted in Chronic leukaemia, Myeloproliferative neoplasm
Tagged BCRABL, CML, splenomegaly, Thrombocytosis, TKI
Leave a comment
Case 52 – update 2
Great discussion so far regarding staging and options for treatment. Overall I think the consensus is to treat this lady with imatinib. The patient commences treatment and BCR-ABL1 shows a major molecular response at 18 months. At this clinic appointment … Continue reading
Posted in Chronic leukaemia, Myeloproliferative neoplasm
Tagged BCRABL, CML, splenomegaly, Thrombocytosis, TKI
Leave a comment