Category Archives: Myeloproliferative neoplasm

Case 100 (part B) – summary

Posted on 02/10/2018 by TeamHaem

Our patient had a mild neutrophilia. Neutrophilia can be seen in: Neonates Infection Especially bacterial (note marrow depletion may occur leading to neutropenia) Inflammation, autoimmune diseases etc. Acute gout Stressed states with high adrenaline e.g. myocardial infarction, exercise, acidosis, eclampsia, … Continue reading →

Posted in Laboratory morphology, Myeloproliferative neoplasm, Related to other specialities | Tagged basophilia, Blood film, chronic myeloid leukaemia, CML, left shift, morphology, neutrophilia, Thrombocytosis

Case 100 (part B) – update

Posted on 02/10/2018 by TeamHaem

Our patient’s neutrophilia/thrombocytosis is attributed to his chest infection. You advise to get a repeat FBC in one month but he forgets and goes to Spain for some ‘winter sun’. On return he has a repeat FBC: Hb 145g/l (115-165) … Continue reading →

Posted in Laboratory morphology, Myeloproliferative neoplasm, Related to other specialities | Tagged basophilia, Blood film, left shift, morphology, neutrophilia, Thrombocytosis

Case 96 – summary

Posted on 19/07/2018 by TeamHaem

Thank you for participating in our case this week. This week we have been looking at a case of JMML (Juvenile myelomonocytic leukaemia), which is a rare clonal haematopoietic disorder of childhood, characterised by the proliferation of granulocytic and monocytic … Continue reading →

Posted in Bone marrow failure, Myeloproliferative neoplasm, Paediatric haematology | Tagged anaemia, Bone marrow, Bone marrow transplant, Cytogenetics, dysplasia, Flow cytometry, genetics, hepatosplenomegaly, JMML, monocytosis, neutrophilia, paediatrics, thrombocytopenia, weight loss

Case 96 – update 4

Posted on 18/07/2018 by TeamHaem

The haematology team has now taken over his care. Bone marrow aspirate has demonstrated a hypercellular marrow with left shift, and there are increased myeloid and monocyte lineages. Blast count is about 4%. There is occasional evidence of haemophagocytosis and … Continue reading →

Posted in Bone marrow failure, Myeloproliferative neoplasm, Paediatric haematology | Tagged anaemia, Cytogenetics, dysplasia, genetics, hepatosplenomegaly, JMML, monocytosis, neutrophilia, paediatrics, thrombocytopenia, weight loss

Case 96 – update 3

Posted on 17/07/2018 by TeamHaem

The blood film has been reported: – leukocytosis with neutrophilia and monocytosis, there is left shift and toxic granulation and vacuolation. Occasional primitive cells ~ 2%. No nucleated RBCs. The appearances might be reactive/infection related, and infection as well as … Continue reading →

Posted in Bone marrow failure, Laboratory morphology, Myeloproliferative neoplasm, Paediatric haematology | Tagged anaemia, Bone marrow, Cytogenetics, dysplasia, Flow cytometry, genetics, hepatosplenomegaly, JMML, monocytosis, neutrophilia, paediatrics, thrombocytopenia, weight loss

Case 96 – update 2

Posted on 16/07/2018 by TeamHaem

An USS abdomen has been performed which confirms mild hepato-splenomegaly. CXR was reported as normal. Faecal elastase, TTG, TFTs, ILGF1 all normal. You phone the haematology registrar to look at the blood film in view of the abnormal FBC. Questions: … Continue reading →

Posted in Bone marrow failure, Laboratory morphology, Myeloproliferative neoplasm, Paediatric haematology | Tagged anaemia, Blood film, dysplasia, hepatosplenomegaly, JMML, monocytosis, neutrophilia, paediatrics, thrombocytopenia, weight loss

Case 89 – summary

Posted on 11/03/2018 by TeamHaem

Thank you for all of the contributions with Case 89 where we encountered a fit 64 year old who presented with progressive anaemia and leucocytosis over the past 6 months. He also had associated weight loss of 0.5 stones … Continue reading →

Posted in Anaemia, Myeloproliferative neoplasm | Tagged anaemia, JAK2, leucocytosis, leucoerythroblastic, Macrocytosis, Myelofibrosis

Case 89 – update 2

Posted on 25/02/2018 by TeamHaem

Thank you for everyone’s contributions so far! Update of investigation results as requested: Bone marrow trephine: myelofibrosis. BM cytogenetics: monosomy 7 Peripheral blood: JAK2 positive. No circulating blasts identified on blood film. USS abdo: 16cm spleen (Hb 95, Plts 90, … Continue reading →

Posted in Anaemia, Myeloproliferative neoplasm, Uncategorised | Tagged anaemia, JAK2, leucocytosis, leucoerythroblastic, Macrocytosis, Myelofibrosis

Case 89 – update 1

Posted on 20/02/2018 by TeamHaem

Thanks for everyones contributions so far. Further information now available as requested by yourselves: Patient decline over past 6 months – 0.5 stone weight loss, no night sweats / fevers. Marked lethargy and generally feeling ‘achey’. Poor appetite but no … Continue reading →

Posted in Anaemia, Laboratory morphology, Myeloproliferative neoplasm | Tagged anaemia, Blood film, leucocytosis, leucoerythroblastic, Macrocytosis

Case 89 – the beginning

Posted on 20/02/2018 by TeamHaem

A 64 year old man is referred to haematology outpatients with progressive chronic anaemia and leucocytosis. He has previously been very fit but has become very lethargic over the past few months. Hb 95, MCV 103, Plts 90, WCC 17, … Continue reading →

Posted in Anaemia, Myeloproliferative neoplasm | Tagged anaemia, leucocytosis, leucoerythroblastic, Macrocytosis

Case 66 – summary

Posted on 22/10/2016 by TeamHaem

Thanks for all who have been involved in this week’s case. We reviewed the causes of thrombocytosis in general and also applicable to pregnancy. Causes of thrombocytosis are usually reactive or secondary to another cause: Blood loss Infection/inflammation Malignancy Thrombopoietin … Continue reading →

Posted in Myeloproliferative neoplasm, Related to other specialities, Thrombosis | Tagged DVT, essential thrombocytosis, iron deficiency, JAK2, LMWH, myeloproliferative, pregnancy, Thrombocytosis, thrombosis, venous thromboembolism

Case 66 – update 3

Posted on 19/10/2016 by TeamHaem

Our patient is diagnosed with essential thrombocythaemia/thrombocytosis (JAK2 V617F positive) and is started on aspirin 75mg od. At 28 weeks she has a painful swollen left leg. It is hot and tender. An ultrasound confirms a deep vein thrombosis. … Continue reading →

Case 66 – update 2

Posted on 18/10/2016 by TeamHaem

All reactive causes of thrombocytosis have been ruled out and our pregnant patient has a persistently elevated platelet count of 500×10*9/L. There is no history of VTE or miscarriage. There are no systemic symptoms such as weight loss, rash or … Continue reading →

Posted in Myeloproliferative neoplasm, Related to other specialities, Thrombosis | Tagged essential thrombocytosis, iron deficiency, JAK2, myeloproliferative, pregnancy, Thrombocytosis

Case 52 – summary

Posted on 28/01/2016 by TeamHaem

Our case was based on a 34 year old lady with a new diagnosis of CML. Diagnosis CML in a proportion of patients is diagnosed on routine blood tests prior to onset of symptoms. However, symptoms can include: lethargy shortness … Continue reading →

Posted in Chronic leukaemia, Myeloproliferative neoplasm | Tagged BCRABL, CML, splenomegaly, Thrombocytosis, TKI | Leave a comment

Case 52 – update 2

Posted on 27/01/2016 by TeamHaem

Great discussion so far regarding staging and options for treatment. Overall I think the consensus is to treat this lady with imatinib. The patient commences treatment and BCR-ABL1 shows a major molecular response at 18 months. At this clinic appointment … Continue reading →