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Category Archives: Myeloproliferative neoplasm
Case 52 – update 1
This patient gives a history of palpitations for the past two days. On questioning she has noted occasional night sweats, and describes some abdominal fullness, but otherwise is usually fit and well with no significant past medical history. She is … Continue reading
Posted in Chronic leukaemia, Myeloproliferative neoplasm
Tagged BCRABL, Blood film, CML, morphology, splenomegaly, Thrombocytosis, TKI
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Case 52 – the beginning
A 34 year old female presents to A&E with a 2 day history of palpitations. Full blood count shows: Hb 84 g/l (135-180) MCV 91 fl (78-100) MCH 29 pg (27-32) Plts 649 x10*9 (150-400) WCC 88 x10*9 (4-11) Differential … Continue reading
Posted in Chronic leukaemia, Myeloproliferative neoplasm
Tagged BCRABL, CML, splenomegaly, Thrombocytosis, TKI
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Case 50 part 4 – summary
The laboratory data of anaemia, thrombocytosis, a leucoerythroblastic film and tear drop poikilocytes point towards a diagnosis of myelofibrosis. Other causes of a leucoerythroblastic film with tear drop poikilocytes may include: Beta thal intermedia/major (this should be obvious from the … Continue reading
Case 50 part 4 – update
#TeamHaem correctly identified the main abnormalities in the film: Tear drop poikilocytes Leucoerythroblastic features (left shifted granulocytes and nucleated red cells) The patient had splenomegaly and was suffering from weight loss and subjective fevers. Questions: Name three possible causes of … Continue reading
Posted in Laboratory morphology, Myeloproliferative neoplasm
Tagged Blood film, leucoerythroblastic, Myelofibrosis
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Case 50 part 4 – the beginning
You are the GP reviewing a patient. He has indigestion and looks pale. A FBC is done: Hb 92g/L (115-160) MCV 76fL (79-98) WCC 15.6×10*9/L (4-11) Neuts 12.6×10*9/L (2-7) PLT 578×10*9/L (150-400) Here is the blood film: Questions: Describe … Continue reading
Morphology week – summary
Slide 1 Answer: Bernard Soulier syndrome, bleeding disorder characterized by thrombocytopenia and large platelets. Autosomal recessive inheritance. Presentation consistent with low or dysfunctional platelets and include easy bruising, nosebleeds, mucosal bleeding, menorrhagia, and, occasionally, GI bleeding. Slide 2 Answer: Hairy cell leukaemia. … Continue reading