Tag Archives: APTT

Case 37 part 1 – update 2

Our patient who is pre-op has had a routine coagulation screen has a prolonged APTT which corrects on mixing with normal plasma, indicating a possible coagulation factor deficiency. If the APTT does not correct it would suggest an antibody interfering … Continue reading

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Case 37 part 1 – update 1

The history is frequently forgotten when worrying about coagulation tests and it is the most important factor. The patient was contacted the next day and he confirms that he has no bleeding problems and is on no medications.  He has … Continue reading

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Case 37 part 1 – the beginning

This week we’re going to present a series of short cases around clotting results. Hopefully we’ll demonstrate when coagulation screens should be used and also how to interpret basic abnormalities. It most be noted that different labs will use different … Continue reading

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Case 26 – summary

A 38 year old man has a routine coagulation test prior to surgery which reveals a prolonged APTT. He has had a major haemostatic challenge without any problems (orthopaedic surgery). First things first – we checked the sample wasn’t clotted, … Continue reading

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Case 26 – update 3

To summarise: 38 year old man with incidental finding of a prolonged APTT on pre-op bloods. History: major orthopaedic surgery without bleeding. Some bleeding post dental extraction but no intervention needed. No family history. Investigations: no LA. Factor assays show … Continue reading

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Case 26 – update 2

Thanks for your comments so far. We have established that our patient is a 38 year old man who is due to go to theatre today. He has an isolated prolongation of his APTT (at 47 secs) and had a … Continue reading

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Case 26 – update 1

So, our patient has a prolonged APTT. There were loads of suggestions and comments from you all about what you would do next. To summarise: Get more information – a reasonable request! A few people highlighted the need to check … Continue reading

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Case 26 – the beginning

You are reviewing a set of coagulation results and note the following: PT 14 APTT 46 Fibrinogen 7 What would you do next? What further information would you like to have? Your answer will depend on whether you are: a … Continue reading

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Case 14 – summary

The idea behind this case was to look at a relatively common problem, prolonged APTT and recognise how we should be acting upon it. There are a number of causes of a prolonged APTT.  In this case the best approach … Continue reading

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Case 14 – update 3

So the APTT corrects on mixing, therefore dome of you have suggested possible factor deficiency.  Which factors would you request levels for. The patient is Day 2 of his hospital stay and the nursing staff have witnessed an episode of … Continue reading

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Case 14 – update 2

Repeat coagulation screen confirms a prolonged APTT, with the remainder of the clotting screen being within normal limits. Mixing studies are performed and the APTT corrects.  What does this show? If the APTT did not correct on mixing what would … Continue reading

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Case 14 – update 1

You review the history taken in the medical note.  This was a 65 year old gentleman who had presented with a 3 week history of lethargy, SOB on exertion and had noted some dark stool on occasions.   You note a … Continue reading

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Case 14 – the beginning

You are an SHO on the medical admissions unit.  You are checking the bloods for a patient, who your colleague reviewed earlier that day.  You notice that the APTT is prolonged on the coagulation screen at 43 seconds. What are … Continue reading

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