Tag Archives: Blood film

Case 100 (part D) – summary

Posted on 05/10/2018 by

The patient had mild thrombocytopenia and has suffered epistaxis. Epistaxis is relatively common and therefore structural causes should also be looked into. This is especially so if the nose bleeds are unilateral. There is a wide differential of why someone … Continue reading →

Posted in Inherited bleeding, Laboratory morphology, Paediatric haematology, Platelet disorders | Tagged , , , , , , , ,

Case 100 (part D) – update

Posted on 05/10/2018 by

You repeat the FBC and it shows similar results Hb 141g/l (130-180) MCV 89fl (82-98) WCC 7.5×109/l (4-11) Neutrophils 4.7×109/l (1.7-7.5) Lymphocytes 2.1×109/l  (1.5-4.5) Platelets 70×109/l (150-450) Coagulation screen – normal U&E/LFT – normal Blood film: Questions What is the … Continue reading →

Posted in Inherited bleeding, Laboratory morphology, Paediatric haematology, Platelet disorders | Tagged , , , , , ,

Case 100 (part C) – update 1

Posted on 03/10/2018 by

Our patient has a mildly elevated lymphocyte count and this is persistent on repeat. In the absence of reactive causes the most likely explanation is a low grade lymphoproliferative neoplasm such as CLL. After a period of monitoring the patient’s … Continue reading →

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , , , ,

Case 100 (part B) – summary

Posted on 02/10/2018 by

Our patient had a mild neutrophilia. Neutrophilia can be seen in: Neonates Infection Especially bacterial (note marrow depletion may occur leading to neutropenia) Inflammation, autoimmune diseases etc. Acute gout Stressed states with high adrenaline e.g. myocardial infarction, exercise, acidosis, eclampsia, … Continue reading →

Posted in Laboratory morphology, Myeloproliferative neoplasm, Related to other specialities | Tagged , , , , , , ,

Case 100 (part B) – update

Posted on 02/10/2018 by

Our patient’s neutrophilia/thrombocytosis is attributed to his chest infection. You advise to get a repeat FBC in one month but he forgets and goes to Spain for some ‘winter sun’. On return he has a repeat FBC: Hb 145g/l (115-165) … Continue reading →

Posted in Laboratory morphology, Myeloproliferative neoplasm, Related to other specialities | Tagged , , , , ,

Case 96 – update 2

Posted on 16/07/2018 by

An USS abdomen has been performed which confirms mild hepato-splenomegaly. CXR was reported as normal. Faecal elastase, TTG, TFTs, ILGF1 all normal. You phone the haematology registrar to look at the blood film in view of the abnormal FBC. Questions: … Continue reading →

Posted in Bone marrow failure, Laboratory morphology, Myeloproliferative neoplasm, Paediatric haematology | Tagged , , , , , , , , ,

Case 90 – summary

Posted on 16/03/2018 by

We started with a 74 year old gentleman who was admitted with weight loss, fatigue and change in bowel habit. A mass in the right iliac fossa was palpated and a colonic malignancy was suspected. He had thrombocytosis with microcytic indices … Continue reading →

Posted in Anaemia, Laboratory morphology, Transfusion | Tagged , , , , , , , , , ,

Case 90 – update 3

Posted on 14/03/2018 by

Our patient is one week post two units of blood and his haemoglobin is back to baseline and has hyperbilirubinaemia. LDH is elevated and haptoglobins are absent. Blood film shows spherocytes. Here is the antibody screen Questions (For fun!) can … Continue reading →

Posted in Anaemia, Laboratory morphology, Transfusion | Tagged , , , , , , , ,

Case 89 – update 1

Posted on 20/02/2018 by

Thanks for everyones contributions so far. Further information now available as requested by yourselves: Patient decline over past 6 months – 0.5 stone weight loss, no night sweats / fevers. Marked lethargy and generally feeling ‘achey’. Poor appetite but no … Continue reading →

Posted in Anaemia, Laboratory morphology, Myeloproliferative neoplasm | Tagged , , , ,

Case 86 – part B2

Posted on 14/11/2017 by

Thanks for joining in with this short case. We reviewed the blood film of an 82 year old. The FBC was done for diabetes monitoring. There was no recent transfusion and no new medications. The film showed red cell agglutination(3) … Continue reading →

Posted in Anaemia, Laboratory morphology, Lymphoma | Tagged , , , ,

Case 86 – part B1

Posted on 13/11/2017 by

An 82 year old gentleman has a routine blood count for diabetes monitoring. This is the blood film.   Questions: What do you see on the blood film? What questions do you want to ask the patient? Any further investigations? … Continue reading →

Posted in Anaemia, Laboratory morphology, Lymphoma | Tagged , , , ,

Case 86 – part A2

Posted on 13/11/2017 by

This short case focused on the diagnosis of thalassaemia over iron deficiency. The below factors can help, but there are many overlapping factors and this is more of a guide rather than absolute. Factors that may make this unreliable include … Continue reading →

Posted in Anaemia, Haemoglobinopathy, Laboratory morphology | Tagged , , , , , , ,

Case 86 – part A1

Posted on 12/11/2017 by

Welcome to #TeamHaem. This week we are going to look at some blood film morphology. A 21 year old female student has a full blood count done due to fatigue. Hb 100g/L MCV 74fl MCH 21.7pg Platelets 250×109/l WCC and … Continue reading →

Posted in Anaemia, Haemoglobinopathy, Laboratory morphology | Tagged , , , , , , ,

Case 80 – summary

Posted on 13/07/2017 by

This week we discussed a 65 year old gentleman who was about to undergo curative surgery for gastric carcinoma. His admission blood tests showed pancytopenia and monocytopenia.   The differential diagnosis of pancytopenia includes: Haematological malignancy e.g. myelodysplasia or infiltration … Continue reading →

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , , , , , , ,

Case 80 – update 3

Posted on 12/07/2017 by

The immunophenotype was: CD20+, CD79b+, CD22+, CD5 negative, FMC7+, CD103+, CD11c+, CD25+, CD10 negative, CD38 negative, lambda sIg+ This is consistent with hairy cell leukaemia. If further immunophenotypic evidence is required additional stains on the trephine can be undertaken (e.g. … Continue reading →

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , , , , , , ,

Case 80 – update 2

Posted on 11/07/2017 by

The blood film showed a population of lymphoid cells with ‘hairy projections’. There was absolute monocytopenia. Both of these are consistent with a diagnosis of hairy cell leukaemia. However, hairy cell leukaemia variant and other low grade lymphoma may have … Continue reading →

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , , , , , , ,

Case 80 – update 1

Posted on 10/07/2017 by

Our patient has pancytopenia. On examination there is no specific findings. There is no palpable lymphadenopathy or hepatosplenomegly. There is no rash or gum infiltration. There are no features of chronic liver disease. However review of recent imaging has noted … Continue reading →

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , , , , , ,

Case 78 – the Beginning

Posted on 03/06/2017 by

A 72 year old lady has attended pre- assessment clinic for an elective hip replacement and had routine bloods taken. Blood results: Hb 93, MCV 97, Plt 220, Wcc 7.5,  Neu 0.9, lymph 6.0. Normal Liver and Renal function  Blood … Continue reading →

Posted in Chronic leukaemia | Tagged , , , ,

Case 77 – summary

Posted on 14/05/2017 by

Case 77 Summary   Thanks to everyone who contributed to the case this week.   Our case started with a blood film to test our morphology skills.  We picked up that the blood film showed: Dysplastic neutrophils Blasts NRBCs Tear … Continue reading →

Posted in Acute leukaemia, Bone marrow failure | Tagged , , , , ,

Case 77 – update 2

Posted on 09/05/2017 by

Bone marrow results: 13% blasts evidence of dysplasia in the erythroid and myeloid cell lines Cytogenetics:trisomy 8   How would you classify this patient? What would be your approach to management?

Posted in Acute leukaemia, Bone marrow failure | Tagged , , , , ,