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Tag Archives: Blood film
Case 96 – update 2
An USS abdomen has been performed which confirms mild hepato-splenomegaly. CXR was reported as normal. Faecal elastase, TTG, TFTs, ILGF1 all normal. You phone the haematology registrar to look at the blood film in view of the abnormal FBC. Questions: … Continue reading
Case 90 – summary
We started with a 74 year old gentleman who was admitted with weight loss, fatigue and change in bowel habit. A mass in the right iliac fossa was palpated and a colonic malignancy was suspected. He had thrombocytosis with microcytic indices … Continue reading
Case 90 – update 3
Our patient is one week post two units of blood and his haemoglobin is back to baseline and has hyperbilirubinaemia. LDH is elevated and haptoglobins are absent. Blood film shows spherocytes. Here is the antibody screen Questions (For fun!) can … Continue reading
Case 89 – update 1
Thanks for everyones contributions so far. Further information now available as requested by yourselves: Patient decline over past 6 months – 0.5 stone weight loss, no night sweats / fevers. Marked lethargy and generally feeling ‘achey’. Poor appetite but no … Continue reading
Posted in Anaemia, Laboratory morphology, Myeloproliferative neoplasm
Tagged anaemia, Blood film, leucocytosis, leucoerythroblastic, Macrocytosis
Case 86 – part B2
Thanks for joining in with this short case. We reviewed the blood film of an 82 year old. The FBC was done for diabetes monitoring. There was no recent transfusion and no new medications. The film showed red cell agglutination(3) … Continue reading
Posted in Anaemia, Laboratory morphology, Lymphoma
Tagged Autoimmune haemolytic anaemia, Blood film, cold haemagglutinin disease, DAT, IgM paraprotein
Case 86 – part B1
An 82 year old gentleman has a routine blood count for diabetes monitoring. This is the blood film. Questions: What do you see on the blood film? What questions do you want to ask the patient? Any further investigations? … Continue reading
Posted in Anaemia, Laboratory morphology, Lymphoma
Tagged Autoimmune haemolytic anaemia, Blood film, cold haemagglutinin disease, DAT, IgM paraprotein
Case 86 – part A2
This short case focused on the diagnosis of thalassaemia over iron deficiency. The below factors can help, but there are many overlapping factors and this is more of a guide rather than absolute. Factors that may make this unreliable include … Continue reading
Posted in Anaemia, Haemoglobinopathy, Laboratory morphology
Tagged anaemia, Blood film, haemoglobinopathy, HbEE, HPLC, microcytosis, morphology, thalassaemia
Case 86 – part A1
Welcome to #TeamHaem. This week we are going to look at some blood film morphology. A 21 year old female student has a full blood count done due to fatigue. Hb 100g/L MCV 74fl MCH 21.7pg Platelets 250×109/l WCC and … Continue reading
Posted in Anaemia, Haemoglobinopathy, Laboratory morphology
Tagged anaemia, Blood film, haemoglobinopathy, HbEE, HPLC, microcytosis, morphology, thalassaemia
Case 80 – summary
This week we discussed a 65 year old gentleman who was about to undergo curative surgery for gastric carcinoma. His admission blood tests showed pancytopenia and monocytopenia. The differential diagnosis of pancytopenia includes: Haematological malignancy e.g. myelodysplasia or infiltration … Continue reading
Case 80 – update 3
The immunophenotype was: CD20+, CD79b+, CD22+, CD5 negative, FMC7+, CD103+, CD11c+, CD25+, CD10 negative, CD38 negative, lambda sIg+ This is consistent with hairy cell leukaemia. If further immunophenotypic evidence is required additional stains on the trephine can be undertaken (e.g. … Continue reading
Case 80 – update 2
The blood film showed a population of lymphoid cells with ‘hairy projections’. There was absolute monocytopenia. Both of these are consistent with a diagnosis of hairy cell leukaemia. However, hairy cell leukaemia variant and other low grade lymphoma may have … Continue reading
Case 80 – update 1
Our patient has pancytopenia. On examination there is no specific findings. There is no palpable lymphadenopathy or hepatosplenomegly. There is no rash or gum infiltration. There are no features of chronic liver disease. However review of recent imaging has noted … Continue reading
Case 78 – the Beginning
A 72 year old lady has attended pre- assessment clinic for an elective hip replacement and had routine bloods taken. Blood results: Hb 93, MCV 97, Plt 220, Wcc 7.5, Neu 0.9, lymph 6.0. Normal Liver and Renal function Blood … Continue reading
Posted in Chronic leukaemia
Tagged autoimmune disease, Blood film, morphology, neutropenia, rheumatoid arthritis
Case 77 – summary
Case 77 Summary Thanks to everyone who contributed to the case this week. Our case started with a blood film to test our morphology skills. We picked up that the blood film showed: Dysplastic neutrophils Blasts NRBCs Tear … Continue reading
Posted in Acute leukaemia, Bone marrow failure
Tagged Blood film, Cytogenetics, dysplasia, leukaemia, morphology, myelodysplasia
Case 77 – update 2
Bone marrow results: 13% blasts evidence of dysplasia in the erythroid and myeloid cell lines Cytogenetics:trisomy 8 How would you classify this patient? What would be your approach to management?
Posted in Acute leukaemia, Bone marrow failure
Tagged Blood film, Cytogenetics, dysplasia, leukaemia, morphology, myelodysplasia
Case 77 – update 1
So far, we have a 54 year old male who is pancytopenic. He demonstrates features of myelodysplasia on blood film. we have not had any clinical details, but most have suggested admission which does not seem unreasonable given the patients … Continue reading
Posted in Acute leukaemia, Bone marrow failure
Tagged Blood film, dysplasia, leukaemia, morphology, myelodysplasia
Case 77 – the beginning
Let’s start this case with a blood film. Can you describe the findings on the film? What information would you like as the registrar reviewing the film? Please reply to us (@TeamHaem) on Twitter and always include #TeamHaem … Continue reading
Posted in Acute leukaemia, Bone marrow failure, Laboratory morphology
Tagged Blood film, morphology
Case 69 – part 2 – summary
This patient has a medical emergency. She has pancytopenia with evidence of bleeding. There are abnormal promyelocytes and faggot cells (below) which are indicative of acute promyelocytic leukaemia. Acute promyelocytic leukaemia is a subtype of acute myeloid leukaemia characterised by … Continue reading
Posted in Acquired bleeding, Acute leukaemia
Tagged Acute myeloid leukaemia, acute promyelocytic leukaemia, AML, APML, Blood film, chemotherapy, coagulopathy, morphology
Case 69 – part 2 – the beginning
A 21 year old female presents with epistaxis and bleeding gums and the following blood count: Hb 69g/L Platelets 27×10*9/L WCC 12×10*9/L Questions What is your immediate management? What tests would you like to perform? Please reply … Continue reading
Posted in Acquired bleeding, Acute leukaemia
Tagged Acute myeloid leukaemia, acute promyelocytic leukaemia, AML, APML, Blood film, chemotherapy, coagulopathy, morphology
