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Tag Archives: Bone marrow
Case 99 – update 3
A bone marrow biopsy has been carried out: (see below) Aspirate shows erythroid hypoplasia but no dysplastic features. Cellularity is normal and megakaryocyte & granulocyte lineages are normal. For interest, also see Trephine IHC with Glycophorin-C staining – demonstrating reduced … Continue reading
Posted in Anaemia, Laboratory morphology, Paediatric haematology
Tagged anaemia, blood transfusion, Bone marrow, morphology, paediatrics
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Case 96 – summary
Thank you for participating in our case this week. This week we have been looking at a case of JMML (Juvenile myelomonocytic leukaemia), which is a rare clonal haematopoietic disorder of childhood, characterised by the proliferation of granulocytic and monocytic … Continue reading
Case 96 – update 3
The blood film has been reported: – leukocytosis with neutrophilia and monocytosis, there is left shift and toxic granulation and vacuolation. Occasional primitive cells ~ 2%. No nucleated RBCs. The appearances might be reactive/infection related, and infection as well as … Continue reading
Case 85 – summary
So, our patient has had quite a week! Thanks to your efforts, he is safely back on the ward, conscious and improving. Recap: We have managed an emergency presentation of an unconscious patient with severe hypercalcaemia, hyperviscosity and an AKI. … Continue reading
Posted in Myeloma/paraproteins
Tagged Bone marrow, delirium, hypercalcaemia, hyperviscosity, myeloma, renal failure
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Case 85 – update 2
We rejoin our patient on HDU… He remains unconscious and lacks capacity to currrently make decisions regarding his further management. Based on our team’s suspicion of an underlying plasma cell disorder, that may be driving our patient’s hypercalcaemia, AKI and … Continue reading
Posted in Myeloma/paraproteins
Tagged Bone marrow, delirium, hypercalcaemia, hyperviscosity, myeloma, renal failure
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Case 75 – update 1
Thanks for everyones contributions. The following results are now back: SFLC kappa: lambda ratio: 6543. Igs and serum electrophoresis: Immuneparesis and IgA kappa paraprotein 18 B2 microglobulin 8.7. Albumin 28. Bone marrow biopsy: 66% plasma cells morphologically. Flow cytometry … Continue reading
Posted in Myeloma/paraproteins
Tagged Bone marrow, Cytogenetics, Flow cytometry, Paraprotein, serum free light chains
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Case 28 – update 2
We had a busy week this week, but have established a diagnosis of Aplastic Anaemia for our young woman. Please see our latest storify if you are interested in our how our discussion evolved (https://storify.com/TeamHaem/case-28) although I will summarise below: … Continue reading
Morphology – case 4
A staging bone marrow aspirate and trephine biopsy is performed for a 15 year old female with Hodgkin Lymphoma. Automated full blood count shows: Hb 135g/L, PLT 467×10*9/L, WCC 15.1×10*9/L, neutrophils 13.2×10*9/L. No evidence of Hodgkin Lymphoma is seen on … Continue reading
Case 18 – update 6
For those with limited morphology experience – how would you describe the findings on the bone marrow? Further testing on bone marrow samples awaited – cytogenetics – which translocation may you find? – cell markers? what would you expect? Urology … Continue reading
Case 18 – update 5
Diagnosis??? what do you do next?
Case 15 – update 5
Bone marrow aspirate confirms your suspicion. Blast count >60%. Flow cytometry results: CD2 – 12% CD 3-8% CD7 – 12% CD10-86% CD13-2% CD19-60% CD33-1% CD34-71% CD64-2% hla-dr-76% TDT- 47% cd79a- 87% What would these markers suggest? In the UK which … Continue reading
Posted in Acute leukaemia, Laboratory morphology, Paediatric haematology
Tagged Bone marrow, Cytogenetics, Paediatric ALL, trials
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Case 15 – update 4
As suggested the blood film is suspicious of leukaemia. You obviously at admit the child for further investigation. You recognise the risk of tumour lysis. You decide to go ahead and perform a bone marrow under sedation. What other investigations/examinations … Continue reading
Posted in Acute leukaemia, Paediatric haematology
Tagged Bone marrow, Paediatric ALL
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Case 12 – summary
Hairy cell leukaemia Hairy cell leukaemia is a chronic lymphoid lymphoma of B-cells The hairy cells infiltrate the reticuloendothelial system and interfere with bone marrow function, resulting in bone marrow failure or pancytopenia. They also infiltrate the spleen and … Continue reading
Posted in Chronic leukaemia, Lymphoma
Tagged Blood film, Bone marrow, Hairy cell leukaemia, immunohistochemistry
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Case 12 – update 6
The trephine shows the typical “fried egg cells” seen in hairy cell leukaemia. The cells appear widely spaced due to abundant cytoplasm, with broad projections. This is typical hairy cell which may be found on the peripheral blood film – although in … Continue reading
Posted in Chronic leukaemia, Laboratory morphology, Lymphoma
Tagged Bone marrow, Hairy cell leukaemia
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