Tag Archives: Cytogenetics

Case 98 – summary

Following several obinutuzumab reactions, which resulted in overnight hospital admissions, our patient decided he did not wish to continue with obinutuzumab. He continues on chlorambucil monotherapy and has tolerated it reasonably well and his disease appears to be responding. Thankyou … Continue reading

Posted in Chronic leukaemia | Tagged , , , , ,

Case 98 – part 2 – update 1

We have confirmed progression in our patient’s CLL. There is no evidence of haemolysis. He has a pmh of HTN, diabetes, mild copd and osteoarthritis which limits his mobility. He has an ecog of 2 (was 1 prior to the … Continue reading

Posted in Chronic leukaemia | Tagged , , , ,

Case 98 – part 2 – the beginning

Thankyou for your help with part 1. Here is the second part of this weeks case. You are in the haematology clinic and are seeing an 82 year old gentleman who was diagnosed with CLL 10 years ago. He has … Continue reading

Posted in Chronic leukaemia | Tagged , , , ,

Case 98 – part 1 – update 3

Our patient has been started on venetoclax and has had an excellent response. Following discussions with our patient and referral to the transplant team he has decided to go ahead with a sibling allo SCT. What considerations are there for … Continue reading

Posted in Chronic leukaemia | Tagged , , , ,

Case 98 – part 1 – update 2

Our patient has been diagnosed with CLL and has been found to have deletion 17p on cytogenetics. He has now been on ibrutinib for 15 months. He has tolerated it very well and did get an improvement in his Hb … Continue reading

Posted in Chronic leukaemia | Tagged , ,

Case 96 – summary

Thank you for participating in our case this week. This week we have been looking at a case of JMML (Juvenile myelomonocytic leukaemia), which is a rare clonal haematopoietic disorder of childhood, characterised by the proliferation of granulocytic and monocytic … Continue reading

Posted in Bone marrow failure, Myeloproliferative neoplasm, Paediatric haematology | Tagged , , , , , , , , , , , , ,

Case 96 – update 4

The haematology team has now taken over his care. Bone marrow aspirate has demonstrated a hypercellular marrow with left shift, and there are increased myeloid and monocyte lineages. Blast count is about 4%. There is occasional evidence of haemophagocytosis and … Continue reading

Posted in Bone marrow failure, Myeloproliferative neoplasm, Paediatric haematology | Tagged , , , , , , , , , ,

Case 96 – update 3

The blood film has been reported: – leukocytosis with neutrophilia and monocytosis, there is left shift and toxic granulation and vacuolation. Occasional primitive cells ~ 2%. No nucleated RBCs. The appearances might be reactive/infection related, and infection as well as … Continue reading

Posted in Bone marrow failure, Laboratory morphology, Myeloproliferative neoplasm, Paediatric haematology | Tagged , , , , , , , , , , , ,

Case 77 – summary

Case 77 Summary   Thanks to everyone who contributed to the case this week.   Our case started with a blood film to test our morphology skills.  We picked up that the blood film showed: Dysplastic neutrophils Blasts NRBCs Tear … Continue reading

Posted in Acute leukaemia, Bone marrow failure | Tagged , , , , ,

Case 77 – update 2

Bone marrow results: 13% blasts evidence of dysplasia in the erythroid and myeloid cell lines Cytogenetics:trisomy 8   How would you classify this patient? What would be your approach to management?

Posted in Acute leukaemia, Bone marrow failure | Tagged , , , , ,

Case 75 – summary

Case 75 – Summary! Thank you for all of the contributions with Case 75, where we encountered a 43 year old who presented with back pain and circulating plasma cells in his peripheral blood. In summary we established that this … Continue reading

Posted in Myeloma/paraproteins | Tagged , , , , , ,

Case 75 – update 1

Thanks for everyones contributions. The following results are now back:   SFLC kappa: lambda ratio: 6543. Igs and serum electrophoresis: Immuneparesis and IgA kappa paraprotein 18 B2 microglobulin 8.7. Albumin 28. Bone marrow biopsy: 66% plasma cells morphologically. Flow cytometry … Continue reading

Posted in Myeloma/paraproteins | Tagged , , , ,

Case 44 – summary

Chronic lymphocytic leukaemia Our case began with a blood film demonstrating small mature lymphocytes, and smear cells, which are findings typical of CLL. The flow cytometry confirmed this diagnosis with a CLL score of 5/5. CD5 + CD23+ Fmc7 negative … Continue reading

Posted in Chronic leukaemia | Tagged , , , , | Leave a comment

Case 44 – update 2

The patient is referred to haematology.  On review you note he has widespread lymphadenopathy, splenomegaly and weight loss.  You decide to commence him on treatment. He has no past medical history and appears fit to undergo chemotherapy. You have requested … Continue reading

Posted in Chronic leukaemia | Tagged , , | Leave a comment

Case 18 – update 6

For those with limited morphology experience – how would you describe the findings on the bone marrow? Further testing on bone marrow samples awaited – cytogenetics – which translocation may you find? – cell markers?  what would you expect? Urology … Continue reading

Posted in Lymphoma | Tagged , , , | 2 Comments

Case 15 – summary

Paediatric ALL In this case, our child presented with a petechial rash.  This can present with a number of different diagnosis therefore a wide differential needs to be formed.  This includes: HSP – Usually a classical distribution of purpura, bruising … Continue reading

Posted in Acute leukaemia, Laboratory morphology, Paediatric haematology | Tagged , , , , | Leave a comment

Case 15 – update 5

Bone marrow aspirate confirms your suspicion.  Blast count >60%. Flow cytometry results: CD2 – 12% CD 3-8% CD7 – 12% CD10-86% CD13-2% CD19-60% CD33-1% CD34-71% CD64-2% hla-dr-76% TDT- 47% cd79a- 87% What would these markers suggest? In the UK which … Continue reading

Posted in Acute leukaemia, Laboratory morphology, Paediatric haematology | Tagged , , , | Leave a comment