Tag Archives: haemoglobinopathy

Case 86 – part A2

This short case focused on the diagnosis of thalassaemia over iron deficiency. The below factors can help, but there are many overlapping factors and this is more of a guide rather than absolute. Factors that may make this unreliable include … Continue reading

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Case 86 – part A1

Welcome to #TeamHaem. This week we are going to look at some blood film morphology. A 21 year old female student has a full blood count done due to fatigue. Hb 100g/L MCV 74fl MCH 21.7pg Platelets 250×109/l WCC and … Continue reading

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Case 73 – summary

This week our case involved the care of a 10 year old girl with SCD who had transfered her care to the UK. She presented in outpatient clinic for the first time and we had to determine her management. During … Continue reading

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Case 73 – update 2 

Given the girls high Right MCA doppler at screening the patient started regular transfusion for prevention of CVA. This was initiated due to Adams et al 1998 NEJM paper that showed a 92% risk reduction in patients with high dopplers … Continue reading

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Case 73 – update 1

Thanks for all your suggestions so far. When the patient was seen for the first time the following was established: History: She is now age 10 and moved to the UK from west Africa a few months ago with her … Continue reading

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Case 73 – the beginning

A 10 year old girl attends paediatric outpatient clinic with a history of Sickle Cell Disease. She was born abroad and has just moved to the UK.  What history should you establish?  What should you note on examination? How would … Continue reading

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Case 45 – summary

This case dealt with two relatively common problems. We had a pregnant patient who was both iron deficient and thrombocytopenic. 1) Iron deficiency in pregnancy Anaemia in pregnancy is fairly common. There can be a 45% increase in plasma volume which will … Continue reading

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Case 45 – update 4

The iron deficiency anaemia has resolved. A ferritin was checked (although not technically necessary) and it was reassuringly well within the normal range indicating adequate iron stores. Now the issue is she is thrombocytopenic in week 36: Hb 118g/L MCV … Continue reading

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Case 45 – update 3

The blood film in the earlier post has been reported as : “Microcytic anaemia with no specific features of iron deficiency or haemoglobinopathy; suggest check iron status” The HPLC shows no variant haemoglobin and the HbA2 is within normal limits … Continue reading

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Case 45 – update 2

So far we have a pregnant lady who is feeling tired and has a microcytic anaemia. It is likely she has iron deficiency. Her family origin questionnaire is done as part of antenatal screening and she states that she is … Continue reading

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Case 45 – update 1

So far we have a women who is 11 weeks pregnant and feeling tired and out of sorts. She has a microcytic anaemia and a borderline platelet count. Firstly let’s think about the anaemia. The two most common causes of … Continue reading

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Case 45 – the beginning

You are in a GP surgery as the GP registrar. A 24 year old female complains of feeling tired. She is eleven weeks pregnant and was due her ‘booking visit’ by the midwife in a one week’s time. She has … Continue reading

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