Tag Archives: Hairy cell leukaemia

Case 80 – summary

Posted on 13/07/2017 by

This week we discussed a 65 year old gentleman who was about to undergo curative surgery for gastric carcinoma. His admission blood tests showed pancytopenia and monocytopenia.   The differential diagnosis of pancytopenia includes: Haematological malignancy e.g. myelodysplasia or infiltration … Continue reading →

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Case 80 – update 3

Posted on 12/07/2017 by

The immunophenotype was: CD20+, CD79b+, CD22+, CD5 negative, FMC7+, CD103+, CD11c+, CD25+, CD10 negative, CD38 negative, lambda sIg+ This is consistent with hairy cell leukaemia. If further immunophenotypic evidence is required additional stains on the trephine can be undertaken (e.g. … Continue reading →

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Case 80 – update 2

Posted on 11/07/2017 by

The blood film showed a population of lymphoid cells with ‘hairy projections’. There was absolute monocytopenia. Both of these are consistent with a diagnosis of hairy cell leukaemia. However, hairy cell leukaemia variant and other low grade lymphoma may have … Continue reading →

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Case 80 – update 1

Posted on 10/07/2017 by

Our patient has pancytopenia. On examination there is no specific findings. There is no palpable lymphadenopathy or hepatosplenomegly. There is no rash or gum infiltration. There are no features of chronic liver disease. However review of recent imaging has noted … Continue reading →

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Case 72- summary

Posted on 12/02/2017 by

Answers A – hereditary elliptocytosis B – hairy cell leukaemia C – metastatic prostate cancer Case A The first case, we started with something relatively straightforward: This was a blood film of a 21 year old pregnant women who was … Continue reading →

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Case 72 – case B

Posted on 06/02/2017 by

A 40 year old gentleman present with the following FBC: WCC 2.9×109/L (4-11) Neuts 0.9×109/L (1.7-7) Lymphocytes 1.4×109/L (1.5-4.5) Monocytes 0.2×109/L (0.2-1) Eosinophils 0.3×109/L (0-0.5) Basophils 0.1×109/L (0-0.1) Hb 55g/L (130-180) MCV 88fL (82-98) Platelets 31×109/L (150-450) His bone marrow … Continue reading →

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Morphology week – summary

Posted on 17/11/2013 by

Slide 1 Answer:  Bernard Soulier syndrome, bleeding disorder characterized by thrombocytopenia and large platelets.  Autosomal recessive inheritance.  Presentation consistent with low or dysfunctional platelets and include easy bruising, nosebleeds, mucosal bleeding, menorrhagia, and, occasionally, GI bleeding. Slide 2 Answer:  Hairy cell leukaemia. … Continue reading →

Posted in Acute leukaemia, Bone marrow failure, Haemoglobinopathy, Laboratory morphology, Lymphoma, Myeloproliferative neoplasm, Platelet disorders | Tagged , , , , , , | Leave a comment

Case 12 – summary

Posted on 12/07/2013 by

Hairy cell leukaemia   Hairy cell leukaemia is a chronic lymphoid lymphoma of B-cells The hairy cells infiltrate the reticuloendothelial system and interfere with bone marrow function, resulting in bone marrow failure or pancytopenia.  They also infiltrate the spleen and … Continue reading →

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Case 12 – update 6

Posted on 08/07/2013 by

The trephine shows the typical “fried egg cells” seen in hairy cell leukaemia.  The cells appear widely spaced due to abundant cytoplasm, with broad projections.   This is typical hairy cell which may be found on the peripheral blood film – although in … Continue reading →

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