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Tag Archives: Hairy cell leukaemia
Case 80 – summary
This week we discussed a 65 year old gentleman who was about to undergo curative surgery for gastric carcinoma. His admission blood tests showed pancytopenia and monocytopenia. The differential diagnosis of pancytopenia includes: Haematological malignancy e.g. myelodysplasia or infiltration … Continue reading
Case 80 – update 3
The immunophenotype was: CD20+, CD79b+, CD22+, CD5 negative, FMC7+, CD103+, CD11c+, CD25+, CD10 negative, CD38 negative, lambda sIg+ This is consistent with hairy cell leukaemia. If further immunophenotypic evidence is required additional stains on the trephine can be undertaken (e.g. … Continue reading
Case 80 – update 2
The blood film showed a population of lymphoid cells with ‘hairy projections’. There was absolute monocytopenia. Both of these are consistent with a diagnosis of hairy cell leukaemia. However, hairy cell leukaemia variant and other low grade lymphoma may have … Continue reading
Case 80 – update 1
Our patient has pancytopenia. On examination there is no specific findings. There is no palpable lymphadenopathy or hepatosplenomegly. There is no rash or gum infiltration. There are no features of chronic liver disease. However review of recent imaging has noted … Continue reading
Case 72 – case B
A 40 year old gentleman present with the following FBC: WCC 2.9×109/L (4-11) Neuts 0.9×109/L (1.7-7) Lymphocytes 1.4×109/L (1.5-4.5) Monocytes 0.2×109/L (0.2-1) Eosinophils 0.3×109/L (0-0.5) Basophils 0.1×109/L (0-0.1) Hb 55g/L (130-180) MCV 88fL (82-98) Platelets 31×109/L (150-450) His bone marrow … Continue reading
Posted in Chronic leukaemia, Lymphoma
Tagged Hairy cell leukaemia, morphology, pancytopenia, Trephine
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Morphology week – summary
Slide 1 Answer: Bernard Soulier syndrome, bleeding disorder characterized by thrombocytopenia and large platelets. Autosomal recessive inheritance. Presentation consistent with low or dysfunctional platelets and include easy bruising, nosebleeds, mucosal bleeding, menorrhagia, and, occasionally, GI bleeding. Slide 2 Answer: Hairy cell leukaemia. … Continue reading
Case 12 – summary
Hairy cell leukaemia Hairy cell leukaemia is a chronic lymphoid lymphoma of B-cells The hairy cells infiltrate the reticuloendothelial system and interfere with bone marrow function, resulting in bone marrow failure or pancytopenia. They also infiltrate the spleen and … Continue reading
Posted in Chronic leukaemia, Lymphoma
Tagged Blood film, Bone marrow, Hairy cell leukaemia, immunohistochemistry
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Case 12 – update 6
The trephine shows the typical “fried egg cells” seen in hairy cell leukaemia. The cells appear widely spaced due to abundant cytoplasm, with broad projections. This is typical hairy cell which may be found on the peripheral blood film – although in … Continue reading
Posted in Chronic leukaemia, Laboratory morphology, Lymphoma
Tagged Bone marrow, Hairy cell leukaemia
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