Tag Archives: hepatosplenomegaly

Case 96 – summary

Thank you for participating in our case this week. This week we have been looking at a case of JMML (Juvenile myelomonocytic leukaemia), which is a rare clonal haematopoietic disorder of childhood, characterised by the proliferation of granulocytic and monocytic … Continue reading

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Case 96 – update 4

The haematology team has now taken over his care. Bone marrow aspirate has demonstrated a hypercellular marrow with left shift, and there are increased myeloid and monocyte lineages. Blast count is about 4%. There is occasional evidence of haemophagocytosis and … Continue reading

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Case 96 – update 3

The blood film has been reported: – leukocytosis with neutrophilia and monocytosis, there is left shift and toxic granulation and vacuolation. Occasional primitive cells ~ 2%. No nucleated RBCs. The appearances might be reactive/infection related, and infection as well as … Continue reading

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Case 96 – update 2

An USS abdomen has been performed which confirms mild hepato-splenomegaly. CXR was reported as normal. Faecal elastase, TTG, TFTs, ILGF1 all normal. You phone the haematology registrar to look at the blood film in view of the abnormal FBC. Questions: … Continue reading

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Case 96 – update 1

This 13 month old boy was born at 39/40 by normal delivery. His birth weight was 2.6kg. He is normally fit and well with no significant problems and no previous hospital admissions. He is up to dates with all his … Continue reading

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Case 16 – summary

This case highlights a number of important points, both in general medicine and haematology. Firstly, the causes of hepatomegaly and splenomegaly are numerous and often not due to a haematological cause.  A list is below. Common causes of hepatosplenomegaly include: … Continue reading

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Case 16 – update 5

The start of case 16 can be found by scrolling down or by clicking a link to the right hand side. Common causes of hepatosplenomegaly include: Hepatitis EBV/CMV Rubella Malaria Leishmaniasis Parasitic infection Myeloproliferative neoplasms Leukaemia Lymphoma Haemoglobinopathies Metabolic diseases including … Continue reading

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