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Tag Archives: leucoerythroblastic
Case 89 – summary
Thank you for all of the contributions with Case 89 where we encountered a fit 64 year old who presented with progressive anaemia and leucocytosis over the past 6 months. He also had associated weight loss of 0.5 stones … Continue reading
Posted in Anaemia, Myeloproliferative neoplasm
Tagged anaemia, JAK2, leucocytosis, leucoerythroblastic, Macrocytosis, Myelofibrosis
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Case 89 – update 2
Thank you for everyone’s contributions so far! Update of investigation results as requested: Bone marrow trephine: myelofibrosis. BM cytogenetics: monosomy 7 Peripheral blood: JAK2 positive. No circulating blasts identified on blood film. USS abdo: 16cm spleen (Hb 95, Plts 90, … Continue reading
Posted in Anaemia, Myeloproliferative neoplasm, Uncategorised
Tagged anaemia, JAK2, leucocytosis, leucoerythroblastic, Macrocytosis, Myelofibrosis
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Case 89 – update 1
Thanks for everyones contributions so far. Further information now available as requested by yourselves: Patient decline over past 6 months – 0.5 stone weight loss, no night sweats / fevers. Marked lethargy and generally feeling ‘achey’. Poor appetite but no … Continue reading
Case 89 – the beginning
A 64 year old man is referred to haematology outpatients with progressive chronic anaemia and leucocytosis. He has previously been very fit but has become very lethargic over the past few months. Hb 95, MCV 103, Plts 90, WCC 17, … Continue reading
Posted in Anaemia, Myeloproliferative neoplasm
Tagged anaemia, leucocytosis, leucoerythroblastic, Macrocytosis
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Case 50 part 4 – summary
The laboratory data of anaemia, thrombocytosis, a leucoerythroblastic film and tear drop poikilocytes point towards a diagnosis of myelofibrosis. Other causes of a leucoerythroblastic film with tear drop poikilocytes may include: Beta thal intermedia/major (this should be obvious from the … Continue reading
Case 50 part 4 – update
#TeamHaem correctly identified the main abnormalities in the film: Tear drop poikilocytes Leucoerythroblastic features (left shifted granulocytes and nucleated red cells) The patient had splenomegaly and was suffering from weight loss and subjective fevers. Questions: Name three possible causes of … Continue reading
Posted in Laboratory morphology, Myeloproliferative neoplasm
Tagged Blood film, leucoerythroblastic, Myelofibrosis
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Case 50 part 4 – the beginning
You are the GP reviewing a patient. He has indigestion and looks pale. A FBC is done: Hb 92g/L (115-160) MCV 76fL (79-98) WCC 15.6×10*9/L (4-11) Neuts 12.6×10*9/L (2-7) PLT 578×10*9/L (150-400) Here is the blood film: Questions: Describe … Continue reading