Tag Archives: Lymphocytosis

Case 100 (part C) – summary

Our patient had a mild lymphocytosis. The differentials include: Reactive – especially viral illnesses Hyposplenism Smoking Polyclonal B cell lymphocytosis – binucleate lymphocytes with isochrome 3q Lymphoproliferative neoplasms such as CLL and other types of lymphoma In the first instance … Continue reading

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged ,

Case 100 (part C) – update 1

Our patient has a mildly elevated lymphocyte count and this is persistent on repeat. In the absence of reactive causes the most likely explanation is a low grade lymphoproliferative neoplasm such as CLL. After a period of monitoring the patient’s … Continue reading

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , , , ,

Case 100 (part C) – the beginning

You are in a GP surgery and are asked to perform a full blood count on a 60 year old male who is awaiting a knee replacement for osteoarthritis. He has a past history of glaucoma, hypertension and a myocardial … Continue reading

Posted in Chronic leukaemia, Lymphoma | Tagged

Case 98 – summary

Following several obinutuzumab reactions, which resulted in overnight hospital admissions, our patient decided he did not wish to continue with obinutuzumab. He continues on chlorambucil monotherapy and has tolerated it reasonably well and his disease appears to be responding. Thankyou … Continue reading

Posted in Chronic leukaemia | Tagged , , , , ,

Case 98 – part 2 – update 1

We have confirmed progression in our patient’s CLL. There is no evidence of haemolysis. He has a pmh of HTN, diabetes, mild copd and osteoarthritis which limits his mobility. He has an ecog of 2 (was 1 prior to the … Continue reading

Posted in Chronic leukaemia | Tagged , , , ,

Case 98 – part 2 – the beginning

Thankyou for your help with part 1. Here is the second part of this weeks case. You are in the haematology clinic and are seeing an 82 year old gentleman who was diagnosed with CLL 10 years ago. He has … Continue reading

Posted in Chronic leukaemia | Tagged , , , ,

Case 98 – part 1 – update 3

Our patient has been started on venetoclax and has had an excellent response. Following discussions with our patient and referral to the transplant team he has decided to go ahead with a sibling allo SCT. What considerations are there for … Continue reading

Posted in Chronic leukaemia | Tagged , , , ,

Case 98 – part 1 – update 2

Our patient has been diagnosed with CLL and has been found to have deletion 17p on cytogenetics. He has now been on ibrutinib for 15 months. He has tolerated it very well and did get an improvement in his Hb … Continue reading

Posted in Chronic leukaemia | Tagged , ,

Case 98 – part 1 – update 1

We have found our patient has a lymphocytosis with mild anaemia and mild thrombocytopenia. Blood film show lymphocytosis with mature lymphocytes and smear cells. We have some flow results. What do these show? What is our diagnosis? Would you like … Continue reading

Posted in Chronic leukaemia, Laboratory morphology | Tagged , ,

Case 95 – summary

Thankyou for all your help this week. This week we had a look at mantle cell lymphoma (MCL). MCL is a type of none Hodgkin’s lymphoma, and comprises between 3 and 10% of NHL, and often has features of both … Continue reading

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , ,

Case 95 – update 2

We have monitored our patient for a year. Unfortunately at his most recent appointment he has begun to complain of weight loss of 7kg, drenching night sweats and fatigue. What would you want to do next? Are there any investigations … Continue reading

Posted in Chronic leukaemia, Lymphoma | Tagged , ,

Case 95 – update 1

So we have found our patient has a lymphocytosis on repeat bloods, we have no historical results. He denies and weight loss, sweats or tiredness. On examination you can feel an enlarged spleen 4cm below the costal margin, but you … Continue reading

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged ,

Case 95 – the beginning

Welcome to our new case! This week we start in GP. We have a 59 year old gentleman who A&E have asked you to follow up as he was found to have a slight lymphocytosis on some bloods that were … Continue reading

Posted in Chronic leukaemia, Lymphoma | Tagged

Case 88 – summary

Morphology week summary. Case A     Our followers were correct in suggesting these were plasma cells, one of which is binucleate on the second picture.  Thrombocytopenia was also noted.  This would be in keeping with a diagnosis of plasma … Continue reading

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma, Myeloma/paraproteins | Tagged , , , , , , , , ,

Case 88 – parts C and D: update

Flow cytometry results. Not true to life I know but just for a bit of fun and test our morphology and flow skills….. The following results are for our two patients- what is the diagnosis for each? Which results goes … Continue reading

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , , , , ,

Case 88 – parts C and D

You are reviewing the blood film tray and a further two patients are noted to have lymphocytosis Case C Hb 96 g/L WCC 34 (10^9/L) Case D Hb 100 g/L WBC 23 (10^9/L) Can you describe the findings? Do they … Continue reading

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , , , , ,

Case 88 – part B: update

As requested by some followers Flow cytometry : CD5 + CD23 – SmIg strong FMC7 ++ CD20 ++ CD22 ++ CD19+ CD79b ++ CD200 ++ CD10- Cyclin D1 expression (11:14)(q13:32)negative Splenomegaly noted on examination, with no evidence of lymphadenopathy.   … Continue reading

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , , ,

Case 88 – part B

84 year old man Hb 111 WBC 24 Describe the findings on the blood film What further clinical information would you wish to know? further investigations?  

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , ,

Case 55 – Summary

This week we met Mr Jones, a 77 year old man who had an abnormal result when he attended his GP for annual well man bloods. His FBC revealed a moderate thrombocytopenia, a slight lymphocytosis and a normochromic anaemia. When … Continue reading

Posted in Chronic leukaemia, Lymphoma | Tagged , , ,

Case 55 – Update

The film for this patient showed moderate sized lymphocytes with frequently clefted nuclei and nucleoli. There were no smear cells. The laboratory staff decided to send the specimen for flow cytometry and obtained the following results: CD5+ CD10- CD19+ CD20+ … Continue reading

Posted in Chronic leukaemia, Lymphoma | Tagged , , , | Leave a comment