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Tag Archives: Macrocytosis
Case 89 – summary
Thank you for all of the contributions with Case 89 where we encountered a fit 64 year old who presented with progressive anaemia and leucocytosis over the past 6 months. He also had associated weight loss of 0.5 stones … Continue reading
Posted in Anaemia, Myeloproliferative neoplasm
Tagged anaemia, JAK2, leucocytosis, leucoerythroblastic, Macrocytosis, Myelofibrosis
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Case 89 – update 2
Thank you for everyone’s contributions so far! Update of investigation results as requested: Bone marrow trephine: myelofibrosis. BM cytogenetics: monosomy 7 Peripheral blood: JAK2 positive. No circulating blasts identified on blood film. USS abdo: 16cm spleen (Hb 95, Plts 90, … Continue reading
Posted in Anaemia, Myeloproliferative neoplasm, Uncategorised
Tagged anaemia, JAK2, leucocytosis, leucoerythroblastic, Macrocytosis, Myelofibrosis
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Case 89 – update 1
Thanks for everyones contributions so far. Further information now available as requested by yourselves: Patient decline over past 6 months – 0.5 stone weight loss, no night sweats / fevers. Marked lethargy and generally feeling ‘achey’. Poor appetite but no … Continue reading
Case 89 – the beginning
A 64 year old man is referred to haematology outpatients with progressive chronic anaemia and leucocytosis. He has previously been very fit but has become very lethargic over the past few months. Hb 95, MCV 103, Plts 90, WCC 17, … Continue reading
Posted in Anaemia, Myeloproliferative neoplasm
Tagged anaemia, leucocytosis, leucoerythroblastic, Macrocytosis
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Case 46 – #UnofficialCSIM2 summary
Thank you to those of you who joined in with this case; we hope it was a useful and enjoyable way to learn. We covered a few important topics during the case: the differential for a macrocytic anaemia Investigating macrocytosis … Continue reading
Posted in Acute leukaemia, Anaemia, Bone marrow failure
Tagged AML, anaemia, Macrocytosis, MDS
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Case 46 – #UnofficialCSIM2: Update 2
Mr Ordie was referred to Haematology clinic after his initial investigations were unremarkable. Bhy this point his Hb was 85g/l with an MCV of 114fl, platelets of 107. A bone marrow biopsy was performed, which showed: . IMAGE: dysplastic red … Continue reading
Posted in Acute leukaemia, Anaemia, Bone marrow failure
Tagged anaemia, Macrocytosis, neutropenia, sepsis
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Case 46 – #UnofficialCSIM2 Update 1
Thanks for all your hard work so far. We’ve established that Mr Ordie has a macrocytic anaemia with normal thyroid function tests, normal B12 and folate and no significant alcohol history. He takes methotrexate and folic acid for rheumatoid arthritis. Methotrexate … Continue reading
Posted in Acute leukaemia, Anaemia, Bone marrow failure
Tagged anaemia, Blood film, Macrocytosis
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Case 46 – #UnofficialCSIM2 Haematology Week
NB To our lonstanding teamhaemers: this week’s case is for medical students. Whilst we may call on some of the usual team to help us out, for now please observe without speaking! Thanks in anticipation.
Posted in Acute leukaemia, Anaemia, Bone marrow failure
Tagged anaemia, b12, Macrocytosis
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Case 17 – summary
This case involved the differential diagnosis of macrocytosis and the investigations needed in order to secure the diagnosis of haemolytic anaemia. Our gentleman presented with fatigue and dyspnoea. On examination he was pale and further blood tests revealed a macrocytic … Continue reading
Case 17 – update 3
Teamhaem have spoken! The film shows polychromasia and enlarged red cells – likely reticulocytes. There are also small contracted cells – spherocytes. Normal red cells should be like the below: Here is our patient’s film: More results: DAT – positive … Continue reading
