Tag Archives: morphology

Case 100 (part D) – summary

Posted on 05/10/2018 by TeamHaem

The patient had mild thrombocytopenia and has suffered epistaxis. Epistaxis is relatively common and therefore structural causes should also be looked into. This is especially so if the nose bleeds are unilateral. There is a wide differential of why someone … Continue reading →

Posted in Inherited bleeding, Laboratory morphology, Paediatric haematology, Platelet disorders | Tagged bleeding, bleeding history, Blood film, epistaxis, Laboratory tests, May Hegglin, morphology, MYH9, thrombocytopenia | Leave a comment

Case 100 (part D) – update

Posted on 05/10/2018 by TeamHaem

You repeat the FBC and it shows similar results Hb 141g/l (130-180) MCV 89fl (82-98) WCC 7.5×109/l (4-11) Neutrophils 4.7×109/l (1.7-7.5) Lymphocytes 2.1×109/l (1.5-4.5) Platelets 70×109/l (150-450) Coagulation screen – normal U&E/LFT – normal Blood film: Questions What is the … Continue reading →

Case 100 (part C) – update 1

Posted on 03/10/2018 by TeamHaem

Our patient has a mildly elevated lymphocyte count and this is persistent on repeat. In the absence of reactive causes the most likely explanation is a low grade lymphoproliferative neoplasm such as CLL. After a period of monitoring the patient’s … Continue reading →

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged Blood film, Flow cytometry, Lymphocytosis, mantle cell lymphoma, morphology | Leave a comment

Case 100 (part B) – summary

Posted on 02/10/2018 by TeamHaem

Our patient had a mild neutrophilia. Neutrophilia can be seen in: Neonates Infection Especially bacterial (note marrow depletion may occur leading to neutropenia) Inflammation, autoimmune diseases etc. Acute gout Stressed states with high adrenaline e.g. myocardial infarction, exercise, acidosis, eclampsia, … Continue reading →

Posted in Laboratory morphology, Myeloproliferative neoplasm, Related to other specialities | Tagged basophilia, Blood film, chronic myeloid leukaemia, CML, left shift, morphology, neutrophilia, Thrombocytosis | Leave a comment

Case 100 (part B) – update

Posted on 02/10/2018 by TeamHaem

Our patient’s neutrophilia/thrombocytosis is attributed to his chest infection. You advise to get a repeat FBC in one month but he forgets and goes to Spain for some ‘winter sun’. On return he has a repeat FBC: Hb 145g/l (115-165) … Continue reading →

Posted in Laboratory morphology, Myeloproliferative neoplasm, Related to other specialities | Tagged basophilia, Blood film, left shift, morphology, neutrophilia, Thrombocytosis | Leave a comment

Case 99 – update 3

Posted on 11/09/2018 by TeamHaem

A bone marrow biopsy has been carried out: (see below) Aspirate shows erythroid hypoplasia but no dysplastic features. Cellularity is normal and megakaryocyte & granulocyte lineages are normal. For interest, also see Trephine IHC with Glycophorin-C staining – demonstrating reduced … Continue reading →

Posted in Anaemia, Laboratory morphology, Paediatric haematology | Tagged anaemia, blood transfusion, Bone marrow, morphology, paediatrics | Leave a comment

Case 97 – Summary

Posted on 04/08/2018 by TeamHaem

This week we looked at a neuropathy presenting via the neurology team associated with a plasma cell dyscrasia. This area of haematology is often challenging! The diagnosis can be difficult and even after diagnosis there is a lack of evidence … Continue reading →

Posted in Lymphoma, Myeloma/paraproteins, Related to other specialities | Tagged anti-MAG, Bone marrow, Flow cytometry, IgM paraprotein, Lymphoma, lymphoplasmacytic lymphoma, morphology, Neurology, neuropathy, Paraprotein, Waldrenstroms | Leave a comment

Case 97 – update 3

Posted on 03/08/2018 by TeamHaem

Thanks for your help so far with this case. so far we know our patient is a 54 year old male who presented to clinic with distal sensory loss and a broad based gait which has been slowly progressing over … Continue reading →

Case 97 – update 2

Posted on 02/08/2018 by TeamHaem

The bone marrow aspirate did appear to show an excess of Plasmacytoid and lymphoplasmacytoid cells. Immunophenotype results: Abnormal population: Kappa restricted B cell population = 18% of total nucleated cells. Immunophenotype: CD19+, CD5 negative, CD23 negative/wk, CD10 negative, CD103 negative, … Continue reading →

Posted in Laboratory morphology, Lymphoma, Myeloma/paraproteins, Related to other specialities | Tagged Bone marrow, Flow cytometry, IgM paraprotein, morphology, Neurology, neuropathy, Paraprotein | Leave a comment

Case 88 – summary

Posted on 13/02/2018 by TeamHaem

Morphology week summary. Case A Our followers were correct in suggesting these were plasma cells, one of which is binucleate on the second picture. Thrombocytopenia was also noted. This would be in keeping with a diagnosis of plasma … Continue reading →

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma, Myeloma/paraproteins | Tagged Chronic lymphocytic leukaemia, CLL, cryoglobulinaemia, Flow cytometry, Lymphocytosis, mantle cell lymphoma, morphology, myeloma, Plasma cell leukaemia, splenic marginal zone lymphoma | Leave a comment

Case 88 – part E

Posted on 09/02/2018 by TeamHaem

Last slide of the week. Spot diagnosis – patient presented with a vasculitis

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged cryoglobulinaemia, Lymphoma, morphology, vasculitis | Leave a comment

Case 88 – parts C and D: update

Posted on 07/02/2018 by TeamHaem

Flow cytometry results. Not true to life I know but just for a bit of fun and test our morphology and flow skills….. The following results are for our two patients- what is the diagnosis for each? Which results goes … Continue reading →

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged Chronic lymphocytic leukaemia, CLL, Flow cytometry, Lymphocytosis, mantle cell lymphoma, morphology | Leave a comment

Case 88 – parts C and D

Posted on 07/02/2018 by TeamHaem

You are reviewing the blood film tray and a further two patients are noted to have lymphocytosis Case C Hb 96 g/L WCC 34 (10^9/L) Case D Hb 100 g/L WBC 23 (10^9/L) Can you describe the findings? Do they … Continue reading →

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged Chronic lymphocytic leukaemia, CLL, Flow cytometry, Lymphocytosis, mantle cell lymphoma, morphology | Leave a comment

Case 88 – part B: update

Posted on 06/02/2018 by TeamHaem

As requested by some followers Flow cytometry : CD5 + CD23 – SmIg strong FMC7 ++ CD20 ++ CD22 ++ CD19+ CD79b ++ CD200 ++ CD10- Cyclin D1 expression (11:14)(q13:32)negative Splenomegaly noted on examination, with no evidence of lymphadenopathy. … Continue reading →

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged Flow cytometry, Lymphocytosis, morphology, splenic marginal zone lymphoma | Leave a comment

Case 88 – part B

Posted on 05/02/2018 by TeamHaem

84 year old man Hb 111 WBC 24 Describe the findings on the blood film What further clinical information would you wish to know? further investigations?

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged Lymphocytosis, morphology, splenic marginal zone lymphoma | Leave a comment

Case 88 – part A

Posted on 04/02/2018 by TeamHaem

This week we are going to do some quick fire morphology cases. Cases will be centered around a blood film, then added questions based on the diagnosis our followers come up with. Please feel free to add interesting pictures of … Continue reading →

Posted in Laboratory morphology, Myeloma/paraproteins | Tagged morphology, myeloma, Plasma cell leukaemia | Leave a comment

Case 86 – part A2

Posted on 13/11/2017 by TeamHaem

This short case focused on the diagnosis of thalassaemia over iron deficiency. The below factors can help, but there are many overlapping factors and this is more of a guide rather than absolute. Factors that may make this unreliable include … Continue reading →

Posted in Anaemia, Haemoglobinopathy, Laboratory morphology | Tagged anaemia, Blood film, haemoglobinopathy, HbEE, HPLC, microcytosis, morphology, thalassaemia | Leave a comment

Case 86 – part A1

Posted on 12/11/2017 by TeamHaem

Welcome to #TeamHaem. This week we are going to look at some blood film morphology. A 21 year old female student has a full blood count done due to fatigue. Hb 100g/L MCV 74fl MCH 21.7pg Platelets 250×109/l WCC and … Continue reading →

Posted in Anaemia, Haemoglobinopathy, Laboratory morphology | Tagged anaemia, Blood film, haemoglobinopathy, HbEE, HPLC, microcytosis, morphology, thalassaemia | Leave a comment

Case 84 – summary

Posted on 19/10/2017 by TeamHaem

Thank you for all your help with this weeks case! This week we looked at a case of a patient with type 1 Gaucher’s disease . She was found to be mildly anaemia with a mild thrombocytopenia. A CT scan … Continue reading →

Posted in Acquired bleeding, Bone marrow failure, Laboratory morphology, Related to other specialities | Tagged Bone marrow, bruising, Gaucher's disease, morphology, splenomegaly, thrombocytopenia | Leave a comment

Case 84 – update 2

Posted on 18/10/2017 by TeamHaem

So we have the results of our patient’s bone marrow and it looks to be consistent with Gaucher’s disease! Our patient has a raised serum ACE and ferritin which is typical of Gaucher’s disease. Our bone marrow shows the typical … Continue reading →