Tag Archives: morphology

Case 100 (part D) – summary

The patient had mild thrombocytopenia and has suffered epistaxis. Epistaxis is relatively common and therefore structural causes should also be looked into. This is especially so if the nose bleeds are unilateral. There is a wide differential of why someone … Continue reading

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Case 100 (part D) – update

You repeat the FBC and it shows similar results Hb 141g/l (130-180) MCV 89fl (82-98) WCC 7.5×109/l (4-11) Neutrophils 4.7×109/l (1.7-7.5) Lymphocytes 2.1×109/l  (1.5-4.5) Platelets 70×109/l (150-450) Coagulation screen – normal U&E/LFT – normal Blood film: Questions What is the … Continue reading

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Case 100 (part C) – update 1

Our patient has a mildly elevated lymphocyte count and this is persistent on repeat. In the absence of reactive causes the most likely explanation is a low grade lymphoproliferative neoplasm such as CLL. After a period of monitoring the patient’s … Continue reading

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Case 100 (part B) – summary

Our patient had a mild neutrophilia. Neutrophilia can be seen in: Neonates Infection Especially bacterial (note marrow depletion may occur leading to neutropenia) Inflammation, autoimmune diseases etc. Acute gout Stressed states with high adrenaline e.g. myocardial infarction, exercise, acidosis, eclampsia, … Continue reading

Posted in Laboratory morphology, Myeloproliferative neoplasm, Related to other specialities | Tagged , , , , , , ,

Case 100 (part B) – update

Our patient’s neutrophilia/thrombocytosis is attributed to his chest infection. You advise to get a repeat FBC in one month but he forgets and goes to Spain for some ‘winter sun’. On return he has a repeat FBC: Hb 145g/l (115-165) … Continue reading

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Case 99 – update 3

A bone marrow biopsy has been carried out: (see below) Aspirate shows erythroid hypoplasia but no dysplastic features. Cellularity is normal and megakaryocyte & granulocyte lineages are normal. For interest, also see Trephine IHC with Glycophorin-C staining – demonstrating reduced … Continue reading

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Case 97 – Summary

This week we looked at a neuropathy presenting via the neurology team associated with a plasma cell dyscrasia. This area of haematology is often challenging! The diagnosis can be difficult and even after diagnosis there is a lack of evidence … Continue reading

Posted in Lymphoma, Myeloma/paraproteins, Related to other specialities | Tagged , , , , , , , , , ,

Case 97 – update 3

Thanks for your help so far with this case. so far we know our patient is a 54 year old male who presented to clinic with distal sensory loss and a broad based gait which has been slowly progressing over … Continue reading

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Case 97 – update 2

The bone marrow aspirate did appear to show an excess of Plasmacytoid and lymphoplasmacytoid cells. Immunophenotype results: Abnormal population: Kappa restricted B cell population = 18% of total nucleated cells. Immunophenotype: CD19+, CD5 negative, CD23 negative/wk, CD10 negative, CD103 negative, … Continue reading

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Case 88 – summary

Morphology week summary. Case A     Our followers were correct in suggesting these were plasma cells, one of which is binucleate on the second picture.  Thrombocytopenia was also noted.  This would be in keeping with a diagnosis of plasma … Continue reading

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Case 88 – part E

Last slide of the week. Spot diagnosis – patient presented with a vasculitis

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Case 88 – parts C and D: update

Flow cytometry results. Not true to life I know but just for a bit of fun and test our morphology and flow skills….. The following results are for our two patients- what is the diagnosis for each? Which results goes … Continue reading

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Case 88 – parts C and D

You are reviewing the blood film tray and a further two patients are noted to have lymphocytosis Case C Hb 96 g/L WCC 34 (10^9/L) Case D Hb 100 g/L WBC 23 (10^9/L) Can you describe the findings? Do they … Continue reading

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Case 88 – part B: update

As requested by some followers Flow cytometry : CD5 + CD23 – SmIg strong FMC7 ++ CD20 ++ CD22 ++ CD19+ CD79b ++ CD200 ++ CD10- Cyclin D1 expression (11:14)(q13:32)negative Splenomegaly noted on examination, with no evidence of lymphadenopathy.   … Continue reading

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Case 88 – part B

84 year old man Hb 111 WBC 24 Describe the findings on the blood film What further clinical information would you wish to know? further investigations?  

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Case 88 – part A

This week we are going to do some quick fire morphology cases. Cases will be centered around a blood film, then added questions based on the diagnosis our followers come up with. Please feel free to add interesting pictures of … Continue reading

Posted in Laboratory morphology, Myeloma/paraproteins | Tagged , ,

Case 86 – part A2

This short case focused on the diagnosis of thalassaemia over iron deficiency. The below factors can help, but there are many overlapping factors and this is more of a guide rather than absolute. Factors that may make this unreliable include … Continue reading

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Case 86 – part A1

Welcome to #TeamHaem. This week we are going to look at some blood film morphology. A 21 year old female student has a full blood count done due to fatigue. Hb 100g/L MCV 74fl MCH 21.7pg Platelets 250×109/l WCC and … Continue reading

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Case 84 – summary

Thank you for all your help with this weeks case! This week we looked at a case of a patient with type 1 Gaucher’s disease . She was found to be mildly anaemia with a mild thrombocytopenia. A CT scan … Continue reading

Posted in Acquired bleeding, Bone marrow failure, Laboratory morphology, Related to other specialities | Tagged , , , , ,

Case 84 – update 2

So we have the results of our patient’s bone marrow and it looks to be consistent with Gaucher’s disease! Our patient has a raised serum ACE and ferritin which is typical of Gaucher’s disease. Our bone marrow shows the typical … Continue reading

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