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Tag Archives: Myelofibrosis
Case 89 – summary
Thank you for all of the contributions with Case 89 where we encountered a fit 64 year old who presented with progressive anaemia and leucocytosis over the past 6 months. He also had associated weight loss of 0.5 stones … Continue reading
Posted in Anaemia, Myeloproliferative neoplasm
Tagged anaemia, JAK2, leucocytosis, leucoerythroblastic, Macrocytosis, Myelofibrosis
Case 89 – update 2
Thank you for everyone’s contributions so far! Update of investigation results as requested: Bone marrow trephine: myelofibrosis. BM cytogenetics: monosomy 7 Peripheral blood: JAK2 positive. No circulating blasts identified on blood film. USS abdo: 16cm spleen (Hb 95, Plts 90, … Continue reading
Posted in Anaemia, Myeloproliferative neoplasm, Uncategorised
Tagged anaemia, JAK2, leucocytosis, leucoerythroblastic, Macrocytosis, Myelofibrosis
Case 50 part 4 – summary
The laboratory data of anaemia, thrombocytosis, a leucoerythroblastic film and tear drop poikilocytes point towards a diagnosis of myelofibrosis. Other causes of a leucoerythroblastic film with tear drop poikilocytes may include: Beta thal intermedia/major (this should be obvious from the … Continue reading
Case 50 part 4 – update
#TeamHaem correctly identified the main abnormalities in the film: Tear drop poikilocytes Leucoerythroblastic features (left shifted granulocytes and nucleated red cells) The patient had splenomegaly and was suffering from weight loss and subjective fevers. Questions: Name three possible causes of … Continue reading
Posted in Laboratory morphology, Myeloproliferative neoplasm
Tagged Blood film, leucoerythroblastic, Myelofibrosis
2 Comments
Case 50 part 4 – the beginning
You are the GP reviewing a patient. He has indigestion and looks pale. A FBC is done: Hb 92g/L (115-160) MCV 76fL (79-98) WCC 15.6×10*9/L (4-11) Neuts 12.6×10*9/L (2-7) PLT 578×10*9/L (150-400) Here is the blood film: Questions: Describe … Continue reading
