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Tag Archives: Paraprotein
Case 91 – summary
Thank you for all your contributions this week! This week we had a look at MGUS (monoclonal gammopathy of undetermined significance). Our patient was diagnosed with IgA lambda MGUS, which was monitored 6 monthly for 4 years. This then progresses … Continue reading
Posted in Myeloma/paraproteins
Tagged MGUS, monoclonal gammopathy, myeloma, Paraprotein
Case 91 – update 2
We have been monitoring our patient 6 monthly for 4 years. His para protein has been slowly rising and was 10g/l on his last visit 3 months ago. He has been bought to clinic slightly earlier to monitor his paraprotein. … Continue reading
Posted in Myeloma/paraproteins
Tagged MGUS, monoclonal gammopathy, myeloma, Paraprotein
Case 91 – update 1
So our patient has been seen by haematology. He initially presented with shoulder pain. Following X-ray and MRI this has been shown to be due to osteoarthritis with no evidence of lytic lesions. Bone marrow had shown a normocellular marrow … Continue reading
Posted in Myeloma/paraproteins
Tagged MGUS, monoclonal gammopathy, myeloma, Paraprotein
Case 91 – the beginning
Welcome to this week’s TeamHaem case! This week we start in general practice. A 70 year old man saw your colleague complaining of shoulder pain. Some bloods were done as he was due his ‘well man’ bloods around the same … Continue reading
Posted in Myeloma/paraproteins
Tagged MGUS, monoclonal gammopathy, myeloma, Paraprotein
Case 75 – update 1
Thanks for everyones contributions. The following results are now back: SFLC kappa: lambda ratio: 6543. Igs and serum electrophoresis: Immuneparesis and IgA kappa paraprotein 18 B2 microglobulin 8.7. Albumin 28. Bone marrow biopsy: 66% plasma cells morphologically. Flow cytometry … Continue reading
Posted in Myeloma/paraproteins
Tagged Bone marrow, Cytogenetics, Flow cytometry, Paraprotein, serum free light chains
Case 69 – part 3 – summary
During this short case we looked at serum protein electrophoresis. This showed a band in the gamma region and immunofixation confirmed a IgM kappa paraprotein. IgM paraproteins are commonly associated with MGUS, low grade lymphoma and rarely myeloma. Typically IgM … Continue reading
Posted in Lymphoma
Tagged electrophoresis, hyperviscosity, IgM paraprotein, Lymphoma, lymphoplasmacytic lymphoma, myeloma, Paraprotein, Waldrenstroms
Case 69 – part 3 – the beginning
Thanks for contributing! Please use #TeamHaem in your reply on Twitter! A 69 year old gentleman presents to his GP with headache and visual blurring. Giant cell arteritis is suspected as the ESR is 120mm/hr. A serum protein electrophoresis … Continue reading
Posted in Lymphoma
Tagged electrophoresis, hyperviscosity, IgM paraprotein, Lymphoma, lymphoplasmacytic lymphoma, myeloma, Paraprotein, Waldrenstroms
Case 62 – summary
Haematological emergencies Patient A presented with an episode of neutropenic sepsis. As a junior you should be suspicious of someone being neutropenic if they have had recent chemotherapy (usually within the past 1-2 weeks). Reviewing patients previous blood results … Continue reading
Case 62 – part B
Case B A 55 year old women attends the Haematology day unit where you are the junior reviewing emergencies. She has a background of IgG MGUS. She has noticed some difficult walking up the stairs over the past few weeks … Continue reading
Posted in Myeloma/paraproteins
Tagged Back pain, Paraprotein, spinal cord compression
Case 50 part 3 – summary
It just goes to show that picking up on simple signs can lead to the start of a diagnostic journey. The patient with the film below (second from left) had a FBC as she had suffered from back pain and … Continue reading
Posted in Laboratory morphology, Myeloma/paraproteins
Tagged Blood film, myeloma, Paraprotein
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Case 50 part 3 – the beginning
You are reviewing the blood films from today. Can you make a diagnosis without a microscope? Please reply to us (@TeamHaem) on Twitter and always include #TeamHaem to allow others to follow your comments. Please join in the … Continue reading
Posted in Laboratory morphology, Myeloma/paraproteins
Tagged Blood film, myeloma, Paraprotein
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Case 48 – #UnofficialCSIM2 update 1
Thanks for joining the case, where as a surgical FY1 doctor you were asked to review Mr Jones, a 75 year old man who had been admitted after a fall leading to a femur fracture. The nurses were worried that … Continue reading
Posted in Myeloma/paraproteins
Tagged fracture, hypercalcaemia, myeloma, Paraprotein
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Case 47 – update 2
So we have another update on our gentleman. He has been found to have nephrotic syndrome and a renal biopsy has been performed which has now come back and is consistent with AL Amyloid nephropathy. Further investigations revealed an IgG … Continue reading
Case 47 – update 1
Here is our first update on our 60 year old gentleman, who only has childhood asthma in his pmh. He initially presented with ankle swelling and despite 20mg furosemide he felt it was getting slightly worse at his second visit. … Continue reading
Case 27 – summary
This case was all about evaluating a patient with a paraprotien. A paraprotein is a specific immunoglobulin produced by a clone of plasma or lymphoid cells. The immunoglobulin is composed of heavy chain and a light chain (either kappa or … Continue reading
Posted in Laboratory morphology, Myeloma/paraproteins
Tagged amyloid, immunofixation, Paraprotein
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