Tag Archives: splenomegaly

Case 84 – summary

Thank you for all your help with this weeks case! This week we looked at a case of a patient with type 1 Gaucher’s disease . She was found to be mildly anaemia with a mild thrombocytopenia. A CT scan … Continue reading

Posted in Acquired bleeding, Bone marrow failure, Laboratory morphology, Related to other specialities | Tagged , , , , ,

Case 84 – update 2

So we have the results of our patient’s bone marrow and it looks to be consistent with Gaucher’s disease! Our patient has a raised serum ACE and ferritin which is typical of Gaucher’s disease. Our bone marrow shows the typical … Continue reading

Posted in Acquired bleeding, Bone marrow failure, Laboratory morphology, Related to other specialities | Tagged , , , , ,

Case 84 – update 1

So we have an update: We have found our patient is thrombocytopenic, and has a mild normocytic anaemia. Our patient has been slightly tired for a year or so, but still manages to do her demanding job as a PE … Continue reading

Posted in Acquired bleeding, Bone marrow failure, Laboratory morphology, Related to other specialities | Tagged , ,

Case 80 – summary

This week we discussed a 65 year old gentleman who was about to undergo curative surgery for gastric carcinoma. His admission blood tests showed pancytopenia and monocytopenia.   The differential diagnosis of pancytopenia includes: Haematological malignancy e.g. myelodysplasia or infiltration … Continue reading

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , , , , , , ,

Case 80 – update 3

The immunophenotype was: CD20+, CD79b+, CD22+, CD5 negative, FMC7+, CD103+, CD11c+, CD25+, CD10 negative, CD38 negative, lambda sIg+ This is consistent with hairy cell leukaemia. If further immunophenotypic evidence is required additional stains on the trephine can be undertaken (e.g. … Continue reading

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , , , , , , ,

Case 80 – update 2

The blood film showed a population of lymphoid cells with ‘hairy projections’. There was absolute monocytopenia. Both of these are consistent with a diagnosis of hairy cell leukaemia. However, hairy cell leukaemia variant and other low grade lymphoma may have … Continue reading

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , , , , , , ,

Case 80 – update 1

Our patient has pancytopenia. On examination there is no specific findings. There is no palpable lymphadenopathy or hepatosplenomegly. There is no rash or gum infiltration. There are no features of chronic liver disease. However review of recent imaging has noted … Continue reading

Posted in Chronic leukaemia, Laboratory morphology, Lymphoma | Tagged , , , , , ,

Case 75 – the beginning

A 43 year old man presents to A+E with severe back pain. He also has a 2 month history of progressive fatigue. On examination he has pallor, splenomegaly and marked tenderness to L2-L5. How would you further assess this patient? … Continue reading

Posted in Myeloma/paraproteins | Tagged , ,

Case 52 – summary

Our case was based on a 34 year old lady with a new diagnosis of CML. Diagnosis CML in a proportion of patients is diagnosed on routine blood tests prior to onset of symptoms.  However, symptoms can include: lethargy shortness … Continue reading

Posted in Chronic leukaemia, Myeloproliferative neoplasm | Tagged , , , , | Leave a comment

Case 52 – update 2

Great discussion so far regarding staging and options for treatment. Overall I think the consensus is to treat this lady with imatinib. The patient commences treatment and BCR-ABL1 shows a major molecular response at 18 months. At this clinic appointment … Continue reading

Posted in Chronic leukaemia, Myeloproliferative neoplasm | Tagged , , , , | Leave a comment

Case 52 – update 1

This patient gives a history of palpitations for the past two days.  On questioning she has noted occasional night sweats, and describes some abdominal fullness, but otherwise is usually fit and well with no significant past medical history.  She is … Continue reading

Posted in Chronic leukaemia, Myeloproliferative neoplasm | Tagged , , , , , ,

Case 52 – the beginning

A 34 year old female presents to A&E with a 2 day history of palpitations.   Full blood count shows: Hb 84 g/l (135-180) MCV 91 fl (78-100) MCH 29 pg (27-32) Plts 649 x10*9 (150-400) WCC 88 x10*9 (4-11) Differential … Continue reading

Posted in Chronic leukaemia, Myeloproliferative neoplasm | Tagged , , , , | Leave a comment

Case 50 part 5 – summary

This case was an interesting one! As haematologists we have a privileged position of being able to get to know our patients extremely well and also have the skills to review their marrow under the microscope in order to reach … Continue reading

Posted in Laboratory morphology, Related to other specialities | Tagged , , , , | Leave a comment

Case 50 part 5 – update

You have a 41 year old female with night sweats, splenomegaly and pancytopenia.   Differential diagnosis from #teamhaem are: Lymphoma e.g. splenic marginal zone lymphoma or hairy cell leukaemia or even a high grade lymphoma Myeloproliferative neoplasm e.g. myelofibrosis Metastatic … Continue reading

Posted in Laboratory morphology, Related to other specialities | Tagged , , , , | Leave a comment

Case 50 part 5 – the beginning

You are the haematologist in a busy clinic. You are referred a patient with splenomegaly and pancytopenia. She has been suffering from night sweats. A full blood count shows: Hb 92g/L (115-160) MCV 89fL (79-98) WCC 2.5×10*9/L (4-11) Neuts 1.0×10*9/L … Continue reading

Posted in Laboratory morphology, Related to other specialities | Tagged , , , , | Leave a comment

Case 12 – update 3

The patient is referred to Haematology and a CT scan is requested.  This confirms splenomegaly with some enlarged mesenteric lymph nodes also identified. A bone marrow biopsy is organised for the following day.  Unfortunately, this is a dry tap and … Continue reading

Posted in Chronic leukaemia, Lymphoma | Tagged , , | Leave a comment

Case 12 – update 1

As the GP, you take a good history from the patient. He is a 48 year old, white british man, previously fit and well. Over the past few months, he has been very lethargic.  He has been managing to work fulltime, … Continue reading

Posted in Chronic leukaemia, Lymphoma | Tagged , , | Leave a comment

Case 12 – the beginning

Working as a GP, you review a 48 year old man.  He complains of symptoms of fatigue and abdominal discomfort.  On examination you find splenomegaly.  How do you proceed? Please reply on Twitter and always include #teamhaem to allow others … Continue reading

Posted in Chronic leukaemia, Lymphoma | Tagged , , | Leave a comment